胶质纤维酸性蛋白基础与临床研究进展

被引：28

作者：

梁彦涛 ^{[1
]}

张敬军 ^{[2
]}

机构：

[1] 江苏省沭阳县人民医院ICU

[2] 泰山医学院

来源：

医学综述 | 2009年 / 15卷 / 16期

关键词：

中枢神经系统; 星形胶质细胞; 胶质纤维酸性蛋白; 脑损伤;

D O I：

暂无

中图分类号：

R741 [神经病学];

学科分类号：

100204 [神经病学];

摘要：

星形胶质细胞(Ast)是中枢神经系统的主要成分之一,具有对各种损害产生强烈反应的特性,胶质纤维酸性蛋白(GFAP)是Ast的骨架蛋白。在生理情况下脑内少有表达,而在病理状态下出现反应性表达增强。GFAP的表达增强是Ast活化增殖的特征性标志,在神经系统发育及病理过程中发挥重要作用,对神经元的存活、突起的再生和神经系统功能的恢复有重要的影响。本文回顾了Ast中GFAP的一般生物学功能,阐述了其与神经系统病变有关的病理生理研究进展。

引用

页码：2407 / 2409

页数：3

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