炎症细胞因子在2型糖尿病发病机制中的研究进展

被引：175

作者：

张黎明

高凌

机构：

[1] 湖北省襄阳市中心医院内分泌科

来源：

重庆医学 | 2016年 / 45卷 / 08期

关键词：

糖尿病,2型; 白细胞介素; 肿瘤坏死因子; C反应蛋白;

D O I：

暂无

中图分类号：

R587.1 [糖尿病];

学科分类号：

100201 [内科学];

摘要：

<正>近来的研究说明2型糖尿病(T2DM)是一种自然免疫及炎症性疾病,是一种"慢性低度炎症状态",认为炎症、免疫与T2DM的发病存在关联[1]。在炎症因子中,除了肿瘤坏死因子(TNF)、白细胞介素(IL)、C反应蛋白(CRP)等作为炎症过程的调节因子外,近年来关于树突状细胞等细胞因子的研究,在T2DM特别是糖尿病大血管病变,如动脉粥样硬化斑块形成发展中的作用也日益受到关注,本文拟对相关机制进展进行综述。1炎症标志物的探讨T2DM的特征是胰岛素抵抗(IR)和进行性β细胞凋亡,二者可能有着共同的发病机制。近几年的研究表明[2],慢性炎症

引用

页码：1113 / 1116

页数：4

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