癫癎持续状态研究热点与新问题

被引:6
作者
韩雁冰
王学峰
机构
[1] 重庆医科大学附属第一医院神经科
关键词
癫癎持续状态; 综述文献;
D O I
暂无
中图分类号
R742.1 [癫痫];
学科分类号
100204 [神经病学];
摘要
<正> 癫癎持续状态(SE)是神经科最为常见的急危重症。持续性癫癎发作不仅可以引起细胞代谢紊乱、葡萄糖和氧耗竭、离子跨膜转运障碍,甚至不能维持细胞正常生理功能,导致神经元死亡,而且还可以合并感染、电解质和酸碱平衡紊乱、呼吸和循环衰竭、肝肾功能障碍等,从而加速机体死亡。生存者也常遗留严重的神经功能障碍,导致难治性癫癎。因此,关于癫癎持续状态的研究一直是癫癎学界最为重要的课题之一。2008年,MEDLINE数据库收录关于癫癎持续状态相关文献共计396篇,其中203篇以癫癎患者作为研究对象。一、癫癎持续状态的新定义与新问题国际抗癫癎联盟(ILAE)最重要的任务之一是制订国际通用的标准化癫癎术语,并以此描述癫癎发作现象。癫癎术语的统一促进了学术交流,成为临床和科研工作中量化分类的基础。2001年,国际抗癫癎联盟提出癫癎持续状态的新定义,即超过这种发作类型大多数患者的持续时间,仍未停止的临
引用
收藏
页码:319 / 322
页数:4
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