Survivin基因及其在肿瘤研究中的意义

被引:39
作者
贾克东
机构
[1] 华中科技大学同济医学院附属同济医院传染科湖北武汉
关键词
凋亡; 肿瘤; 基因治疗; Survivin;
D O I
暂无
中图分类号
R730.5 [肿瘤治疗学];
学科分类号
100214 ;
摘要
Survivin基因是一种新的凋亡抑制基因 ,在肿瘤形成过程中与细胞凋亡的抑制和细胞增生有关 ,早期出现于肿瘤组织细胞中 ,并成为某些肿瘤预后不良的标志。在体内和体外研究中 ,针对Survivin的反义核酸及其突变体可以诱导细胞凋亡 ,降低肿瘤生长的能力 ,增强肿瘤细胞对化疗药物的敏感性 ,因此该基因有可能成为肿瘤诊断和治疗的新的靶位。
引用
收藏
页码:338 / 341
页数:4
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