HPLC法测定盐酸二甲双胍肠溶胶囊及片剂的人体药代动力学及其生物利用度

被引：42

作者：

刘京

申竹芳

谢明智

机构：

[1] 中国医学科学院药物研究所!北京

来源：

中国临床药理学杂志 | 1994年 / 03期

关键词：

盐酸二甲双胍; 肠溶胶囊; 相对生物利用度; 反相高效液相色谱法;

D O I：

10.13699/j.cnki.1001-6821.1994.03.007

中图分类号：

R969.1 [药物代谢动力学];

学科分类号：

摘要：

11例健康男性志愿者,随机分为两组,分别交叉口服盐酸二甲双胍肠溶胶囊和片剂,用反相高效液相色谱法测定血浆样品,进行生物利用度研究.结果表明,口服两种剂型后药物均能很快吸收,口服1000mg盐酸二甲双胍肠溶胶囊和片剂的达峰时间（Tpeak）分别为2.28±0.38h和2.03±0.40h;峰浓度（Cmax）为2.52±0.90mg/l和2.38±0.74mg/l;口服两种剂型的吸收迟滞时间（Tlag）分别为0.47±0.11和0.35±0.32h;二者的药时曲线下面积（AUC）分别为12.74士4.28mg·h-1·L-1和12.70±5.03mg·h-1·L-1;消除半衰期(T1/2)分别为1.74±0.49h和1.98土0.76h ;经t检验,两种剂型的药代动力学参数无显著性差异,口服盐酸二甲双肌肠溶胶囊对其片剂的相对生物利用度为100.3%.

引用

页码：165 / 170

页数：6

共 8 条

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