腰椎间盘退变分子生物学因素研究进展

被引：15

作者：

马秀才

沈霖

机构：

[1] 华中科技大学同济医学院附属协和医院

来源：

中国矫形外科杂志 | 2011年 / 19卷 / 17期

关键词：

腰椎间盘退变; 分子生物学; 炎性因子; 基质金属蛋白酶; 生长因子;

D O I：

暂无

中图分类号：

R681.53 [];

学科分类号：

摘要：

<正>近年来,随着分子生物学和分子免疫学技术研究的深入,多数学者认为影响椎间盘退变的分子机制主要包括以下几个因素,即促进基质分解的因素如炎症因子、基质金属蛋白酶(matrix metalloproteinase,MMPS)等;抑制基质分解的因素如基质蛋白酶抑制剂(matrix metalloproteinase inhibitors,TIMP),促进细胞分裂的因素如血小板源性生长因子(plate-let-derived growth factor,PDGF),促进软骨形成因素如转化生长因子(transforming growth factor,TGF)、骨形态发生蛋白

引用

页码：1451 / 1453

页数：3

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