Toll样受体与肝纤维化

被引:4
作者
许深深
叶波平
机构
[1] 中国药科大学生命科学与技术学院
关键词
TLR4; TLR9; TLR3; TLR2; TLR7; 肝纤维化;
D O I
暂无
中图分类号
R575.2 [肝硬变];
学科分类号
100201 [内科学];
摘要
各种急、慢性的肝损伤会激活肝脏中的免疫相关细胞,如Kupffer细胞,通过释放的大量炎症因子激活肝星状细胞(Hepatic stellate cells,HSCs),HSCs进一步转化为肌成纤维细胞,分泌大量细胞外基质(ECM)如Ⅰ型胶原,最终过量ECM累积导致肝纤维化的发生。Toll样受体(To11-like receptors,TLRs)是人体内重要的先天免疫识别受体,与炎症反应和纤维化形成过程中的信号传递关系密切,其各亚型对肝纤维化的作用不尽相同。文章根据近年来的文献报道,就TLR4、9、3、2、7与肝纤维化的关系加以综述。
引用
收藏
页码:589 / 592
页数:4
相关论文
共 24 条
[1]
Gut-liver axis and fibrosis in nonalcoholic fatty liver disease: An input for novel therapies[J] Otilia E. Frasinariu;Sara Ceccarelli;Anna Alisi;Evelina Moraru;Valerio Nobili Digestive and Liver Disease 2013,
[2]
Goose Toll-like receptor 7 (TLR7); myeloid differentiation factor 88 (MyD88) and antiviral molecules involved in anti-H5N1 highly pathogenic avian influenza virus response[J] Liangmeng Wei;Peirong Jiao;Runyu Yuan;Yafen Song;Pengfei Cui;Xuchen Guo;Bofang Zheng;Weixin Jia;Wenbao Qi;Tao Ren;Ming Liao Veterinary Immunology and Immunopathology 2013,
[3]
Advances in research of fish immune-relevant genes: A comparative overview of innate and adaptive immunity in teleosts[J] Lv-yun Zhu;Li Nie;Guan Zhu;Li-xin Xiang;Jian-zhong Shao Developmental and Comparative Immunology 2013,
[4]
Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway[J] Haitao Shi;Lei Dong;Jiong Jiang;Juhui Zhao;Gang Zhao;Xiaoyan Dang;Xiaolan Lu;Miao Jia Toxicology 2013,
[5]
1142 RIBAVIRIN IS A TLR7 AGONIST AND ITS ANTIVIRAL EFFECT ON HCV IS AT LEAST PARTLY RELATED TO THE INDUCTION OF IRF7 EXPRESSION[J] S. Chevaliez;P. Bensadoun;A. Belle;J.-M. Pawlotsky Journal of Hepatology 2013,
[6]
Toll-Like Receptor 2–Mediated Intestinal Injury and Enteric Tumor Necrosis Factor Receptor I Contribute to Liver Fibrosis in Mice[J] Phillipp Hartmann;Michael Haimerl;Magdalena Mazagova;David A. Brenner;Bernd Schnabl Gastroenterology 2012,
[7]
Protective effects of curcumin against hepatic fibrosis induced by carbon tetrachloride: Modulation of high-mobility group box 1; Toll-like receptor 4 and 2 expression[J] Chuan-tao Tu;Qun-yan Yao;Bei-li Xu;Ji-yao Wang;Chao-hui Zhou;Shun-cai Zhang Food and Chemical Toxicology 2012,
[8]
A High-Cholesterol Diet Exacerbates Liver Fibrosis in Mice via Accumulation of Free Cholesterol in Hepatic Stellate Cells[J] Toshiaki Teratani;Kengo Tomita;Takahiro Suzuki;Tetsuya Oshikawa;Hirokazu Yokoyama;Katsuyoshi Shimamura;Susumu Tominaga;Sadayuki Hiroi;Rie Irie;Yoshikiyo Okada;Chie Kurihara;Hirotoshi Ebinuma;Hidetsugu Saito;Ryota Hokari;Kazuo Sugiyama;Takanori Kanai;Soichiro Miura;Toshifumi Hibi Gastroenterology 2012,
[9]
The Type of Dietary Fat Modulates Intestinal Tight Junction Integrity; Gut Permeability; and Hepatic Toll‐Like Receptor Expression in a Mouse Model of Alcoholic Liver Disease[J] Irina A.Kirpich;WenkeFeng;YuhuaWang;YanlongLiu;David F.Barker;Shirish S.Barve;Craig J.McClain Alcoholism: Clinical and Experimental Research 2012,
[10]
Animal models for the study of hepatic fibrosis[J] Peter Starkel;I.A. Leclercq Best Practice & Research Clinical Gastroenterology 2011,