bcl-2、bax、caspase-3在细胞凋亡中的作用及其关系

被引：388

作者：

董雅洁 ^{[1
]}

高维娟 ^{[2
]}

机构：

[1] 承德医学院病理生理学教研室

[2] 河北化工医药职业技术学院

来源：

中国老年学杂志 | 2012年 / 32卷 / 21期

关键词：

bcl-2; bax; caspase-3; 细胞凋亡;

D O I：

暂无

中图分类号：

R363 [病理生理学];

学科分类号：

100103 [病原生物学];

摘要：

<正>细胞凋亡是细胞在一定的生理或病理条件下,受多种基因精确调控的主动的、程序化的死亡过程,是机体重要的自稳调节机制〔1〕。近年来通过大量实验研究表明,线粒体通路在细胞存亡机制中起着至关重要的作用,而在众多的凋亡调控基因中,bcl-2蛋白家族和胱天蛋白酶(caspase)家族目前最受关注,

引用

收藏

页码：4828 / 4830

页数：3

相关论文

共 13 条

[1]

bcl-2/bax基因调控机体细胞凋亡的机制研究进展 [J].

王彤 ;

刘存志 ;

刘玉珍 ;

于建春 ;

韩景献 .

中国老年学杂志, 2008, (16) :1658-1660

[2]

Effects of Ethyl Pyruvate on Myocardial Apoptosis and Expression of Bcl-2 and Bax Proteins after Ischemia-reperfusion in Rats.[J].郭家龙;张凯伦;季艳梅;蒋雄刚;左顺庆;.Journal of Huazhong University of Science and Technology(Medical Sciences).2008, 03

[3]

The Proapoptotic BCL-2 Homology Domain 3-Only Protein Bim Is Not Critical for Acute Excitotoxic Cell Death [J].

Theofilas, Panos ;

Bedner, Peter ;

Huttmann, Kerstin ;

Theis, Martin ;

Steinhauser, Christian ;

Frank, Stephan .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2009, 68 (01) :102-110

[4]

Modulation of Effector Caspase Cleavage Determines Response of Breast and Lung Tumor Cell Lines to Chemotherapy [J].

Odonkor, Charles A. ;

Achilefu, Samuel .

CANCER INVESTIGATION, 2009, 27 (04) :417-429

[5]

Catalytically active Yersinia outer protein P induces cleavage of RIP and caspase-8 at the level of the DISC independently of death receptors in dendritic cells [J].

Groebner, Sabine ;

Adkins, Irena ;

Schulz, Sebastian ;

Richter, Kathleen ;

Borgmann, Stefan ;

Wesselborg, Sebastian ;

Ruckdeschel, Klaus ;

Micheau, Olivier ;

Autenrieth, Ingo B. .

APOPTOSIS, 2007, 12 (10) :1813-1825

[6]

Apoptotic effect of 3,4-dihydroxybenzoic acid on human gastric carcinoma cells involving JNK/p38 MAPK signaling activation [J].

Lin, Hui-Hsuan ;

Chen, Jing-Hsien ;

Huang, Chi-Chou ;

Wang, Chau-Jong .

INTERNATIONAL JOURNAL OF CANCER, 2007, 120 (11) :2306-2316

[7]

Bcl-2 enhances neurogenesis and inhibits apoptosis of newborn neurons in adult rat brain following a transient middle cerebral artery occlusion [J].

Zhang, Rong ;

Xue, Yu-Yu ;

Lu, Shi-Duo ;

Wang, Yao ;

Zhang, Ling-Mei ;

Huang, Ya-Lin ;

Signore, Armando P. ;

Chen, Jun ;

Sun, Feng-Yan .

NEUROBIOLOGY OF DISEASE, 2006, 24 (02) :345-356

[8]

Molecular mechanism of 'mitocan'-induced apoptosis in cancer cells epitomizes the multiple roles of reactive oxygen species and Bcl-2 family proteins [J].

Neuzil, Jiri ;

Wang, Xiu-Fang ;

Dong, Lan-Feng ;

Low, Pauline ;

Ralph, Stephen J. .

FEBS LETTERS, 2006, 580 (22) :5125-5129

[9]

Mitochondrial function in apoptotic neuronal cell death [J].

Haeberlein, SLB .

NEUROCHEMICAL RESEARCH, 2004, 29 (03) :521-530

[10]

Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain [J].

Ricci, JE ;

Muñoz-Pinedo, C ;

Fitzgerald, P ;

Bailly-Maitre, B ;

Perkins, GA ;

Yadava, N ;

Scheffler, IE ;

Ellisman, MH ;

Green, DR .

CELL, 2004, 117 (06) :773-786