OPG-RANKL-RANK系统与绝经后骨质疏松症

被引：17

作者：

商敏

机构：

[1] 首都医科大学附属北京友谊医院妇产科

来源：

中国骨质疏松杂志 | 2008年 / 07期

关键词：

护骨素; 绝经后骨质疏松症;

D O I：

暂无

中图分类号：

R580 [];

学科分类号：

1002 ; 100201 ;

摘要：

雌激素减少导致的骨丢失增加是绝经后骨质疏松症的主要发病原因,OPG-RANKL-RANK系统的发现是骨骼生理研究领域的重大进展,作为雌激素对骨骼作用的中间环节,在绝经后骨质疏松症的发病中发挥重要作用。OPG基因与其他候选基因一样,与绝经后骨质疏松症的遗传易感性有关,可望被用于筛查绝经后骨质疏松症的高危人群。OPG还有可能成为新的生化标记物来预测绝经后骨质疏松症并用于评价疗效。本文针对以上问题对OPG-RANKL-RANK系统在绝经后骨质疏松症发生中的作用及其应用综述如下。

引用

页码：532 / 535

页数：4

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