黄芪甲苷对心肌钙离子通道中活性氧引起的直接氧化作用的影响

被引：5

作者：

张博雅

王超

董阳

李景照

机构：

[1] 天津市南开医院心内一科

来源：

黑龙江医学 | 2018年 / 42卷 / 11期

关键词：

黄芪甲苷; 过氧化氢; 心肌细胞; 钙离子通道;

D O I：

暂无

中图分类号：

R285 [中药药理学];

学科分类号：

100806 [中药药理学];

摘要：

目的探讨黄芪甲苷(AS-IV)影响活性氧引起的钙通道直接氧化作用。方法利用膜片钳膜内面向外式记录方式,研究AS-IV(10μmol/L)对过氧化氢(H2O2)直接氧化钙离子通道活性的影响。结果 1 mmol/L H2O2能引起钙离子通道钙电流的增加(P <0. 05),10μmol/L AS-IV并未明显影响H2O2引起离子通道钙电流的增加。结论 AS-IV并未对ROS引起的钙通道直接氧化作用产生影响,AS-IV参与钙通道钙离子内释放,从而起到维持正常心脏功能的作用。

引用

页码：1042 / 1043+1056 +1056

页数：3

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