绝经后糖脂代谢异常妇女雌激素受体α基因多态性观察

被引：2

作者：

秦燕 ^{[1
]}

田玉峰 ^{[1
]}

孙树凯 ^{[2
]}

翟木绪 ^{[1
]}

机构：

[1] 山东省日照市人民医院检验科

[2] 青岛大学医学院附属医院黄岛分院检验科

来源：

中华全科医师杂志 | 2014年 / 13卷 / 02期

关键词：

雌激素受体;

D O I：

暂无

中图分类号：

R589 [代谢病]; R440 [];

学科分类号：

100201 [内科学];

摘要：

采用PCR–限制性片段长度多态性(RFLP)技术, 检测270例查体汉族绝经后女性的雌激素受体(ER)基因型。结果显示, Pp、pp基因型者血清TG、LDL–C水平显著高于PP基因型者, 178例糖脂代谢异常者的p等位基因分布频率显著高于代谢正常者。

引用

共 7 条

[1]

Correlations between genetic variance and adiposity measures, and gene × gene interactions for obesity in postmenopausal Vietnamese women [J].

Binh T.Q. ;

Nakahori Y. ;

Hien V.T.T. ;

Khan N.C. ;

Lam N.T. ;

Mai L.B. ;

Yamamoto S. .

Journal of Genetics, 2011, 90 (1) :1-9

[2]

Association between ESR1 and ESR2 gene polymorphisms and hyperlipidemia in Chinese Han postmenopausal women [J].

Zhao, Teng ;

Zhang, Di ;

Liu, Yun ;

Zhou, Daizhan ;

Chen, Zhuo ;

Yang, Yifeng ;

Li, Sheng ;

Yu, Lan ;

Zhang, Zuofeng ;

Feng, Guoyin ;

He, Lin ;

Xu, He .

JOURNAL OF HUMAN GENETICS, 2010, 55 (01) :50-54

[3]

Association of polymorphisms in genes involved in lipoprotein metabolism with plasma concentrations of remnant lipoproteins and HDL subpopulations before and after hormone therapy in postmenopausal women [J].

Lamon-Fava, Stefania ;

Asztalos, Bela F. ;

Howard, Timothy D. ;

Reboussin, David M. ;

Horvath, Katalin V. ;

Schaefer, Ernst J. ;

Herrington, David M. .

CLINICAL ENDOCRINOLOGY, 2010, 72 (02) :169-175

[4]

Association of ER-Alpha Gene Polymorphism with Metabolic Phenotypes in Chinese Hans [J].

Chen, Yan ;

Jiang, Xiao-yan ;

Xu, Li ;

Li, Xia ;

Cao, Fei-fei ;

Li, Lei ;

Lu, Ming ;

Jin, Li ;

Wang, Xiao-feng .

LIPIDS, 2009, 44 (08) :719-723

[5]

Estrogen receptor 1 gene polymorphisms and decreased risk of obesity in women [J].

Goulart, Alessandra C. ;

Zee, Robert Y. L. ;

Rexrode, Kathryn M. .

METABOLISM-CLINICAL AND EXPERIMENTAL, 2009, 58 (06) :759-764

[6]

女性雌激素受体α基因多态性分布特征及血脂关系研究 [J].

白永恒 ;

黄友泽 ;

陆红 ;

吴琦 ;

刘乐平 ;

陈必成 .

中国卫生检验杂志, 2010, 20 (12) :3128-3130

[7]

Estrogen receptor alpha gene polymorphism associated with type 2 diabetes mellitus and the serum lipid concentration in Chinese women in Guangzhou.[J]..Chinese Medical Journal.2006, 21

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