肝细胞癌患者中NLRC5的表达及其临床意义

被引：5

作者：

汪欢

俞广进

熊奇如

机构：

[1] 安徽医科大学第一附属医院

来源：

肝胆外科杂志 | 2018年 / 26卷 / 02期

关键词：

肝细胞癌; NLRC5; 免疫组化学; Western blot; 预后;

D O I：

暂无

中图分类号：

R735.7 [肝肿瘤];

学科分类号：

100112 [医学生物化学与分子生物学];

摘要：

目的探讨核苷酸结合结构域受体家族含CARD结构域-5(NLRC5)在肝细胞癌组织中表达情况及与临床病理特征、预后的关系。方法采用免疫组化SP法检测94例肝细胞癌组织及其癌旁正常组织中NLRC5的表达;Western blot检测20例新鲜肝细胞癌组织及其对应的癌旁正常组织中NLRC5的表达。结果 NLRC5在肝细胞癌组织中的阳性率(62.77%)显著高于癌旁正常组织(19.15%,P<0.01);NLRC5的表达与肝细胞癌分化程度、TNM分期、有无硬化有关(P<0.05),与患者年龄、性别、AFP值、肿瘤大小、HBV感染、肿瘤包膜是否完整无关(P>0.05)。肝细胞癌组织中蛋白相对表达量(0.280±0.049)明显高于相应癌旁正常组织中(0.038±0.009,P<0.01)。NLRC5阳性患者的3年生存期明显低于阴性患者(P<0.01),并且NLRC5为肝细胞癌预后的独立性危险因素。结论 NLRC5蛋白在肝细胞癌组织中高表达,且与患者的临床病理特征、预后等因素有关,可能在肝细胞癌发生、发展过程中起着重要作用,有望成为肝细胞癌新的肿瘤标志物和潜在的治疗靶点。

引用

页码：149 / 153

页数：5

共 12 条

[1]

NLRC5/MHC class I transactivator is a target for immune evasion in cancer [J].

Yoshihama, Sayuri ;

Roszik, Jason ;

Downs, Isaac ;

Meissner, Torsten B. ;

Vijayan, Saptha ;

Chapuy, Bjoern ;

Sidiq, Tabasum ;

Shipp, Margaret A. ;

Lizee, Gregory A. ;

Kobayashi, Koichi S. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (21) :5999-6004

[2]

Cancer Statistics in China, 2015 [J].

Chen, Wanqing ;

Zheng, Rongshou ;

Baade, Peter D. ;

Zhang, Siwei ;

Zeng, Hongmei ;

Bray, Freddie ;

Jemal, Ahmedin ;

Yu, Xue Qin ;

He, Jie .

CA-A CANCER JOURNAL FOR CLINICIANS, 2016, 66 (02) :115-132

[3]

NLRC5 regulates TGF-β1-induced proliferation and activation of hepatic stellate cells during hepatic fibrosis.[J].Tao Xu;Ming-ming Ni;Xing-Li;Xiao-feng Li;Xiao-ming Meng;Cheng Huang;Jun Li.International Journal of Biochemistry and Cell Biology.2016,

[4]

NLRC5 expression in tumors and its role as a negative prognostic indicator in stage III non-small-cell lung cancer patients [J].

Li, Xiaoyu ;

Guo, Fuchun ;

Liu, Yongmei ;

Chen, Hui-Jiao ;

Wen, Feng ;

Zou, Binwen ;

Li, Dan ;

Qin, Qin ;

Liu, Xiaoke ;

Shen, Yali ;

Wang, Yongsheng .

ONCOLOGY LETTERS, 2015, 10 (03) :1533-1540

[5]

Signaling pathways bridging microbial-triggered inflammation and cancer [J].

Kipanyula, Maulilio John ;

Etet, Paul Faustin Seke ;

Vecchio, Lorella ;

Farahna, Mohammed ;

Nukenine, Elias Nchiwan ;

Kamdje, Armel Herve Nwabo .

CELLULAR SIGNALLING, 2013, 25 (02) :403-416

[6]

Fibrosis-dependent mechanisms of hepatocarcinogenesis [J].

Zhang, David Y. ;

Friedman, Scott L. .

HEPATOLOGY, 2012, 56 (02) :769-775

[7]

Management of HCC.[J].Carlos Rodríguez de Lope;Silvia Tremosini;Alejandro Forner;María Reig;Jordi Bruix.Journal of Hepatology.2012,

[8]

NLRC5 deficiency selectively impairs MHC class I- dependent lymphocyte killing by cytotoxic T cells..[J].Staehli Francesco;Ludigs Kristina;Heinz Leonhard X;Seguín-Estévez Queralt;Ferrero Isabel;Braun Marion;Schroder Kate;Rebsamen Manuele;Tardivel Aubry;Mattmann Chantal;MacDonald H Robson;Romero Pedro;Reith Walter;Guarda Greta;Tschopp Jürg.Journal of immunology (Baltimore; Md. : 1950).2012, 8

[9]

Molecular Classification and Novel Targets in Hepatocellular Carcinoma: Recent Advancements [J].