IL-23/IL-17轴与心肌缺血再灌注损伤的研究进展

被引：12

作者：

张文艳

胡钢英

机构：

[1] 武汉大学人民医院心内科武汉大学心血管病研究所心血管病湖北省重点实验室

来源：

医学研究杂志 | 2018年 / 47卷 / 01期

关键词：

IL-23/IL-17轴; 心肌缺血再灌注损伤; 炎性反应;

D O I：

暂无

中图分类号：

R54 [心脏、血管（循环系）疾病];

学科分类号：

100201 [内科学];

摘要：

白细胞介素23(IL-23)/IL-17轴是在研究炎性反应及免疫应答中新发现的重要信号通路,IL-23能促进辅助性T细胞生成分泌IL-17,促进炎性反应。大量研究表明IL-23/IL-17轴在多种慢性炎性疾病、自身免疫性疾病起重要作用。近年来多项研究证实IL-23/IL-17轴中的重要因子IL-23、IL-17在心肌缺血再灌注损伤中表达明显增高,IL-23/IL-17轴与心肌缺血再灌注损伤的发生、发展密切相关,并有望成为新的治疗靶标。进步深入研究IL-23/IL-17轴对心肌缺血再灌注损伤的防治具有重要意义。本文现将IL-23/IL-17轴与心肌缺血再灌注损伤的研究进展综述如下。

引用

页码：9 / 12+107 +107

页数：5

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