胰岛β细胞转录因子FoxO1的研究进展

被引:17
作者
郑舒静
陈诺琦
机构
[1] 福建医科大学附属漳州市医院内分泌科
关键词
FoxO1; β细胞; 增殖; 分化; 氧化应激;
D O I
暂无
中图分类号
R587.1 [糖尿病];
学科分类号
100201 [内科学];
摘要
转录因子FoxO1是叉头家族O的亚族成员之一,是胰岛素/胰岛素样生长因子信号通路中的关键分子。FoxO1蛋白主要有磷酸化、乙酰化和泛素化3种不同形式的共价修饰,这3种修饰方式在调节FoxO1蛋白分子转录活性和信号转导过程中发挥着重要的作用。FoxO1在胰岛β细胞中表达丰富,与其生长增殖、凋亡、分化、应对氧化应激等密切相关。FoxO1作为胰岛β细胞中特异的转录因子,研究其在β细胞中的表达及作用,将为糖尿病的预防和诊治带来新的契机。
引用
收藏
页码:47 / 49
页数:3
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