Hepatocellular carcinoma and non-alcoholic steatohepatitis:The state of play

被引:6
作者
Bérénice Charrez [1 ]
Liang Qiao [2 ]
Lionel Hebbard [1 ,2 ]
机构
[1] Department of Molecular and Cell Biology, James Cook University
[2] Westmead Millennium Institute, Westmead Hospital and University of Sydney
基金
英国医学研究理事会;
关键词
Non-alcoholic steatohepatitis; Hepatocellular carcinoma; Non-alcoholic fatty liver disease; Models; Mice;
D O I
暂无
中图分类号
R575.5 [肝代谢障碍];
学科分类号
1002 ; 100201 ;
摘要
Hepatocellular carcinoma(HCC) is now the fifth cancer of greatest frequency and the second leading cause of cancer related deaths worldwide. Chief amongst the risks of HCC are hepatitis B and C infection, aflatoxin B1 ingestion, alcoholism and obesity. The latter can promote non-alcoholic fatty liver disease(NAFLD), that can lead to the inflammatory form non-alcoholic steatohepatitis(NASH), and can in turn promote HCC. The mechanisms by which NASH promotes HCC are only beginning to be characterized. Here in this review, we give a summary of the recent findings that describe and associate NAFLD and NASH with the subsequent HCC progression. We will focus our discussion on clinical and genomic associations that describe new risks for NAFLD and NASH promoted HCC. In addition, we will consider novel murine models that clarify some of the mechanisms that drive NASH HCC formation.
引用
收藏
页码:2494 / 2502
页数:9
相关论文
共 30 条
[1]  
Trends in Burden of Cirrhosis and Hepatocellular Carcinoma by Underlying Liver Disease in US Veterans, 2001–2013[J] . Lauren A. Beste,Steven L. Leipertz,Pamela K. Green,Jason A. Dominitz,David Ross,George N. Ioannou.Gastroenterology . 2015 (6)
[2]   Histone Deacetylase HDAC8 Promotes Insulin Resistance and β-Catenin Activation in NAFLD-Associated Hepatocellular Carcinoma [J].
Tian, Yuan ;
Wong, Vincent W. S. ;
Wong, Grace L. H. ;
Yang, Weiqin ;
Sun, Hanyong ;
Shen, Jiayun ;
Tong, Joanna H. M. ;
Go, Minnie Y. Y. ;
Cheung, Yue S. ;
Lai, Paul B. S. ;
Zhou, Mingyan ;
Xu, Gang ;
Huang, Tim H. M. ;
Yu, Jun ;
To, Ka F. ;
Cheng, Alfred S. L. ;
Chan, Henry L. Y. .
CANCER RESEARCH, 2015, 75 (22) :4803-4816
[3]   Statin use and non-alcoholic steatohepatitis in at risk individuals [J].
Dongiovanni, Paola ;
Petta, Salvatore ;
Mannisto, Ville ;
Mancina, Rosellina Margherita ;
Pipitone, Rosaria ;
Karja, Vesa ;
Maggioni, Marco ;
Kakela, Pirjo ;
Wiklund, Olov ;
Mozzi, Enrico ;
Grimaudo, Stefania ;
Kaminska, Dorota ;
Rametta, Raffaela ;
Craxi, Antonio ;
Fargion, Silvia ;
Nobili, Valerio ;
Romeo, Stefano ;
Pihlajamaki, Jussi ;
Valenti, Luca .
JOURNAL OF HEPATOLOGY, 2015, 63 (03) :705-712
[4]   Regular exercise decreases liver tumors development in hepatocyte-specific PTEN-deficient mice independently of steatosis [J].
Piguet, Anne-Christine ;
Saran, Uttara ;
Simillion, Cedric ;
Keller, Irene ;
Terracciano, Luigi ;
Reeves, Helen L. ;
Dufour, Jean-Francois .
JOURNAL OF HEPATOLOGY, 2015, 62 (06) :1296-1303
[5]   The role of fructose in metabolism and cancer [J].
Charrez, Berenice ;
Qiao, Liang ;
Hebbard, Lionel .
HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION, 2015, 22 (02) :79-89
[6]   Oxidative stress promotes pathologic polyploidization in nonalcoholic fatty liver disease [J].
Gentric, Geraldine ;
Maillet, Vanessa ;
Paradis, Valerie ;
Couton, Dominique ;
L'Hermitte, Antoine ;
Panasyuk, Ganna ;
Fromenty, Bernard ;
Celton-Morizur, Severine ;
Desdouets, Chantal .
JOURNAL OF CLINICAL INVESTIGATION, 2015, 125 (03) :981-992
[7]   Transmembrane 6 Superfamily Member 2 Gene Variant Disentangles Nonalcoholic Steatohepatitis From Cardiovascular Disease [J].
Dongiovanni, Paola ;
Petta, Salvatore ;
Maglio, Cristina ;
Fracanzani, Anna Ludovica ;
Pipitone, Rosaria ;
Mozzi, Enrico ;
Motta, Benedetta Maria ;
Kaminska, Dorota ;
Rametta, Raffaela ;
Grimaudo, Stefania ;
Pelusi, Serena ;
Montalcini, Tiziana ;
Alisi, Anna ;
Maggioni, Marco ;
Karja, Vesa ;
Boren, Jan ;
Kakela, Pirjo ;
Di Marco, Vito ;
Xing, Chao ;
Nobili, Valerio ;
Dallapiccola, Bruno ;
Craxi, Antonio ;
Pihlajamaki, Jussi ;
Fargion, Silvia ;
Sjostrom, Lars ;
Carlsson, Lena M. ;
Romeo, Stefano ;
Valenti, Luca .
HEPATOLOGY, 2015, 61 (02) :506-514
[8]  
Nonalcoholic Steatohepatitis is the Second Leading Etiology of Liver Disease Among Adults Awaiting Liver Transplantation in the U.S[J] . Robert J. Wong,Maria Aguilar,Ramsey Cheung,Ryan B. Perumpail,Stephen A. Harrison,Zobair M. Younossi,Aijaz Ahmed.Gastroenterology . 2014
[9]   Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome [J].
Yki-Jarvinen, Hannele .
LANCET DIABETES & ENDOCRINOLOGY, 2014, 2 (11) :901-910
[10]  
Dietary effects on liver tumor burden in mice treated with the hepatocellular carcinogen diethylnitrosamine[J] . Marin E. Healy,Jenny D.Y. Chow,Frances L. Byrne,David S. Breen,Norbert Leitinger,Chien Li,Carolin Lackner,Stephen H. Caldwell,Kyle L. Hoehn.Journal of Hepatology . 2014