蛋白酶激活受体-2调控肠黏膜屏障损伤相关疾病的研究进展

被引：7

作者：

张烁

吕宾

机构：

[1] 浙江中医药大学附属第一医院消化内科

来源：

中华消化杂志 | 2014年 / 34卷 / 01期

关键词：

D O I：

暂无

中图分类号：

R574 [肠疾病];

学科分类号：

100201 [内科学];

摘要：

<正>黏膜屏障由完整的肠上皮细胞和相邻肠上皮细胞间的连接构成。肠道内存在多种蛋白酶,可通过激活G蛋白耦联受体产生多种生物学效应。蛋白酶激活受体(proteinaseactivated receptor,PAR)-2是一种7次跨膜的G蛋白耦联受体,属于PAR家族,在体内分布广泛。多种肠道内富含的蛋白酶能激活PAR-2并产生多种生物学效应,从而影响肠屏障功能。一、PAR-2在消化道的表达PAR-2介导跨膜信号转导。胰蛋白酶、肥大细胞类胰蛋白酶是有效的PAR-2激动剂,可水解PAR-2细胞外区的N2

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