冠心病患者糖基化白蛋白与肿瘤坏死因子-α水平的关系

被引：3

作者：

蒲里津 ^{[1
]}

陆林 ^{[2
]}

沈卫峰 ^{[2
]}

张奇 ^{[2
]}

张瑞岩 ^{[2
]}

陈秋静 ^{[2
]}

机构：

[1] 昆明医学院第一附属医院心内科

[2] 上海交通大学医学院附属瑞金医院心内科

来源：

微循环学杂志 | 2008年 / 04期

关键词：

糖基化白蛋白; 肿瘤坏死因子-α; 冠心病; 炎症;

D O I：

暂无

中图分类号：

R541.4 [冠状动脉（粥样）硬化性心脏病（冠心病）];

学科分类号：

1002 ; 100201 ;

摘要：

目的:探讨冠心病患者血清糖基化白蛋白(GA)与肿瘤坏死因子-α(TNF-α)水平之间的关系。方法:用病例对照研究方法,以冠脉造影确诊的冠心病患者200例为冠心病组,以200例无糖尿病及冠心病人群为对照组,测定各组血清白蛋白(Albumin)、GA及TNF-α水平,分析上述各指标之间及与冠心病的关系。结果:冠心病组血清GA15.74%(95%CI15.43～16.01);TNF-α79.23±7.63ng/L(95%CI68.17～91.26)分别高于对照组GA14.71%(95%CI14.51～14.92,P<0.01)和TNF-α64.05±5.81ng/L(95%CI55.31～72.04,P<0.05)。血清GA与TNF-α水平呈正相关(r=0.346;校正年龄和血糖后,偏相关系数r=0.339,P<0.01),多元逐步回归分析提示,TNF-α水平对血清GA水平影响最显著(β=0.334,P<0.01),GA是唯一对TNF-α水平有显著影响的变量(β=0.347,P<0.01)。结论:冠心病患者血清GA水平显著升高,且与TNF-α水平正相关,可能与冠心病患者的炎症状态有关。

引用

页码：46 / 48+77+80 +77

页数：5

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