紫外线对人角朊细胞和成纤维细胞抗原成分表达的影响

被引：4

作者：

周华

朱惠刚

张振农

机构：

[1] 上海医科大学!,上海医科大学!,上海市公共卫生监督所

来源：

环境与健康杂志 | 1999年 / 06期

关键词：

紫外线; 角朊细胞; 成纤维细胞; 免疫荧光;

D O I：

10.16241/j.cnki.1001-5914.1999.06.002

中图分类号：

R363 [病理生理学];

学科分类号：

摘要：

为深入探讨ＵＶＡ对皮肤光老化的作用机制，采用不同剂量的ＵＶＡ（３２０４００ｎｍ）照射人角朊细胞和成纤维细胞，通过免疫组化方法，观察ＵＶＡ对一些抗原成分表达的影响。结果显示，当ＵＶＡ照射剂量达到２７Ｊ／ｃｍ２时，角朊细胞的多种抗原成分表达下降；当ＵＶＡ剂量为３Ｊ／ｃｍ２时，成纤维细胞表达Ⅰ型和Ⅲ型胶原下降，当ＵＶＡ为９Ｊ／ｃｍ２时，成纤维细胞表达的Ⅰ和Ⅲ型胶原几乎消失。充分说明了ＵＶＡ在皮肤光老化中的重要作用

引用

页码：322 / 324

页数：3

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