运动适应中AMPK分子调控机制的研究进展

被引:7
作者
孙静 [1 ]
刘志二 [2 ]
机构
[1] 河北大学体育教研部
[2] 吉林体育学院运动人体科学系
关键词
AMPK; AMP/ATP比值; 运动适应; 骨骼肌; 分子调控机制;
D O I
暂无
中图分类号
G804.6 [运动生物力学];
学科分类号
040211 [体育与运动心理学];
摘要
运动应激导致机体骨骼肌细胞内的相对能量平衡状态遭到破坏,机体恢复相对能量平衡状态对机体运动能力的保持具有重要意义。AMPK在运动适应过程中对调节细胞能量代谢和物质代谢,维持细胞自稳态具有重要作用。在一次性运动中AMPK的激活具有运动强度依赖性和运动时间依赖性。AMP/ATP比值改变是运动适应过程中AMPK激活的主要机制,Cr/PCr比值、葡萄糖等细胞内其他能量物质状态、H+浓度变化和LKB1等骨骼肌AMPK上位激酶的变化对AMPK激活也有影响。阐明了在运动适应过程中AMPK分子调控机制方面的研究进展。
引用
收藏
页码:73 / 76+80 +80
页数:5
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