首次脑梗死患者和正常健康者血清超敏C-反应蛋白的性别差异及其意义

被引:4
作者
秦晓凌
黄文娟
张侠
蔚志刚
机构
[1] 徐州市中心医院
关键词
超敏C-反应蛋白; 脑梗死; 炎症反应; 性别差异;
D O I
10.16636/j.cnki.jinn.2011.01.011
中图分类号
R743.3 [急性脑血管疾病(中风)];
学科分类号
摘要
目的探讨首次脑梗死患者与正常健康体检者血清超敏C-反应蛋白(hsCRP)的性别差异及意义。方法选取1 3 8例首次脑梗死患者(NIHSS评分<5分)作为脑梗死组,将其分为男性组和女性组。选取1 5 0例健康体检者作为正常组,亦分为男性组和女性组。检测各组患者血清hsCRP水平。结果脑梗死组血清hsCRP水平明显高于正常组(P<0.05)。男性脑梗死组与女性脑梗死组血清hsCRP相比较差异无统计学意义(P>0.0 5)。男性正常组与女性正常组血清hsCRP相比较,男性组高于女性组,差异有统计学意义(P<0.0 5)。男性脑梗死组与男性正常组血清hsCRP相比较差异无统计学意义(P>0.0 5)。女性脑梗死组与女性正常组血清hsCRP相比较差异有统计学意义(P<0.0 5)。结论血清hsCRP水平存在性别差异。炎症反应与女性脑梗死的发病可能有着更为密切的联系。
引用
收藏
页码:24 / 28
页数:5
相关论文
共 9 条
[2]  
Gender Differences in Acute Ischemic Stroke: Etiology, Stroke Patterns and Response to Thrombolysis[J] . Stroke . 2009 (7)
[3]  
Seasonal and Sex Variation of High-Sensitivity C-Reactive Protein in Healthy Adults: A Longitudinal Study[J] . Chiriboga,David E,Ma,Yunsheng,Li,Wenjun,Stanek,Edward J,Hébert,James R,Merriam,Philip A,Rawson,Eric S,Ockene,Ira S.Clinical Chemistry . 2009 (2)
[4]  
High-Sensitivity C-Reactive Protein Is Independently Associated With Early Carotid Artery Progression in Women But Not in Men: The INVADE Study[J] . Kerstin Sander,Carla Schulze Horn,Claus Briesenick,Dirk Sander.Stroke . 2007 (11)
[5]   Effects of estrogen against LPS-induced inflammation and toxicity in primary rat glial and neuronal cultures [J].
Tenenbaum, Meytal ;
Azab, Abed N. ;
Kaplanski, Jacob .
JOURNAL OF ENDOTOXIN RESEARCH, 2007, 13 (03) :158-166
[6]   The relative strength of C-reactive protein and lipid levels as determinants of ischemic stroke compared with coronary heart disease in women [J].
Everett, Brendan M. ;
Kurth, Tobias ;
Buring, Julie E. ;
Ridker, Paul M. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2006, 48 (11) :2235-2242
[7]   C-reactive protein levels among women of various ethnic groups living in the United States - (from the Women's Health Study) [J].
Albert, MA ;
Glynn, RJ ;
Buring, J ;
Ridker, PM .
AMERICAN JOURNAL OF CARDIOLOGY, 2004, 93 (10) :1238-1242
[8]   Gender difference in C-reactive protein concentrations in individuals with atherothrombotic risk factors and apparently healthy ones [J].
Rogowski, O ;
Zeltser, D ;
Shapira, I ;
Burke, M ;
Zakut, V ;
Mardi, T ;
Ben-Assayag, E ;
Serov, J ;
Rozenblat, M ;
Berliner, S .
BIOMARKERS, 2004, 9 (01) :85-92
[9]  
Relation between markers of systemic vascular inflammation and smoking in women[J] . Edmund A. Bermudez,Nader Rifai,Julie E. Buring,JoAnn E. Manson,Paul M. Ridker.The American Journal of Cardiology . 2002 (9)