NLRP3炎症小体在肝疾病中的作用

被引:16
作者
孔德龙 [1 ]
崔洁 [2 ]
机构
[1] 徐州医科大学病原生物学与免疫学教研室江苏省免疫与代谢重点实验室
[2] 徐州医科大学生理学教研室
关键词
肝脏疾病; NLRP3炎症小体; 信号通路;
D O I
暂无
中图分类号
R575 [肝及胆疾病];
学科分类号
100201 [内科学];
摘要
NLRP3炎症小体是一种多蛋白复合物,能识别来自损伤细胞和病原生物释放的信号分子,介导caspase-1活化,从而剪切活化细胞因子IL-1β和IL-18。IL-1β是一种正反馈式促炎因子,可放大炎症反应。与其他炎症反应不同,NLRP3炎症小体活化需要两种信号参与,因而具有较高的激活阈值。NLRP3炎症小体活化与肝疾病发病机制有密切关系,在不同病因诱导的肝疾病及实验动物模型研究中已证明,NLRP3炎症小体活化在肝细胞损伤、细胞活化以及促进肝纤维化中发挥重要作用。这些研究有助于转化应用到临床治疗实践中,为肝疾病的治疗提供理论依据和新的药物作用靶点。本文主要探讨了炎症小体的功能、活化机制及其不同肝损伤过程中的活化及生物学功能效应,并根据国内外最新相关研究报道,对NLRP3炎症小体在酒精性肝病、非酒精性肝病、慢性HCV感染和肝纤维化中的作用进行综述。
引用
收藏
页码:129 / 134
页数:6
相关论文
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