实验性腰神经根压迫模型的建立

被引:46
作者
王拥军
万超
沈培芝
王海彬
石印玉
施杞
机构
[1] 上海中医药大学骨伤科研究所!
[2] 上海
关键词
动物模型; 压迫; 神经根;
D O I
暂无
中图分类号
R-332 [医用实验动物学];
学科分类号
1001 ;
摘要
为探明腰椎间盘突出等压迫因素对腰神经根挤压及产生下肢放射痛的机理作者选择了32只大鼠,随机分为对照组、4天观察组、10天观察组和30天观察组。通过手术切除L4,5棘突,咬除椎板及L4,5右侧关节突后,暴露马尾神经及L5神经根,置硅胶片于L5神经根和硬膜囊连接处,观察造模后4天、10天、30天时大鼠下肢神经功能和压迫局部的病理变化情况,证实了该动物模型的成功,确立了硅胶片压迫腰神经根模型的建立,从而为研究腰椎间盘突出及根性神经痛提供了较理想的模型。
引用
收藏
页码:9 / 12
页数:4
相关论文
共 9 条
[1]  
Incision of the fibrosusinduces nerve root morphologic, vascular, and functionalchanges. Kayama S,Konno S,Olmarker K,et al. SPINE . 1996
[2]  
Pathophysiology of sciatica. Olmarker K,Rydevik B. Orthopedic Clinics of North America . 1991
[3]  
Vasogenic edema induced by compression injurt to the spinal nerve root: Distributionof intravenously injected protein tracers and gadolinium-en-hanced magnetic imaging. Kobayashi S,Yoshizawa H,Hachlya Y,et al. SPINE . 1993
[4]  
Spinal nerve root compresion-nutrition and functionof the porcine cauda equina compressed in vivo. Olmark K. Acta Orthopaedica Scandinavica . 1991
[5]  
Increased resistance to acute compression injury in chronically compressed spinal nerveroot. Kikuchi S,Konnoa S,Kayama SA,et al. SPINE . 1996
[6]  
The intrinsic vasculature of the lumbascral spinal nerve roots. Parke WW,Watanabe R. SPINE . 1985
[7]  
A model for chronicnerve root compression studies:presentation of a porcine modelfor controlled,slow-onset compression with analyses ofanatomic aspects,compression onset rate,and morphologic andneurophysioloic effects. Cornefjord M,Sato K,Olmarker K,et al. SPINE . 1997
[8]  
Sensory afferent impulse originate from dorsalroot ganglia as well as from the periphery in normal and nerve injuried rats. Wall PD,Devor M. Pain . 1983
[9]  
Structural properties of spinalnerve root:protein composition. Stodieck LS,Beel JA,Luttges MW. Experimental Neurology . 1986