结肠癌根治术后化疗联合自体级联诱发免疫细胞治疗对患者预后的影响

被引:6
作者
舒新成 [1 ]
高萍 [2 ]
左新华 [3 ]
机构
[1] 河南省安阳市第六人民医院普外科
[2] 河南中医学院第一附属医院
[3] 重庆迪安医学检验中心有限公司
关键词
结肠癌根治术; 自体级联诱发免疫细胞; 肿瘤标志物; 血管新生; 红细胞免疫;
D O I
10.13210/j.cnki.jhmu.20160301.004
中图分类号
R735.35 [];
学科分类号
摘要
目的:研究结肠癌根治术后化疗联合自体级联诱发免疫细胞治疗对患者预后的影响。方法:选择2012年5月2014年12月期间在我院接受结肠癌根治术辅助术后化疗的78例结肠癌患者进行治疗,随机分为两组,联合治疗组进行化疗联合自体级联诱发免疫细胞治疗,单纯化疗组进行FOLFOX方案化疗,测定血清中肿瘤标志物含量、血管新生分子含量以及外周血中红细胞免疫功能指标。结果:联合治疗组患者血清中肿瘤标志物CCSA-2、CCSA-3、CCSA-4、PTN、NGAL、sMICA以及血管新生分子VEGF、FGF10、sICAM-1、sVCAM-1、Musashi1、Dkk1的含量低于常规化疗组(均P<0.05);联合治疗组患者外周血中CR1、CR3、CD58、CD59比例以及红细胞C3b受体花环形成率、免疫复合物花环形成率均显著高于常规化疗组(均P<0.05)。结论:结肠癌根治术后化疗联合自体级联诱发免疫细胞治疗有助于杀伤肿瘤细胞、抑制血管新生,同时增强红细胞免疫功能,对结肠癌根治术的预后具有改善作用。
引用
收藏
页码:1733 / 1736
页数:4
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