阿托伐他汀对慢性阻塞性肺疾病合并肺动脉高压患者的临床作用及其机制

被引：23

作者：

马航

何海艳

邱海艳

陶一江

机构：

[1] 南通市第一人民医院呼吸科

来源：

山西医科大学学报 | 2014年 / 45卷 / 03期

关键词：

慢性阻塞性肺疾病; 肺动脉高压; 炎症; 氧化应激; 白介素-6; 8-异前列腺素;

D O I：

暂无

中图分类号：

R563.9 [其他];

学科分类号：

100201 [内科学];

摘要：

目的观察阿托伐他汀在治疗慢性阻塞性肺疾病(COPD)合并肺动脉高压(PH)患者中的临床价值并分析其可能的作用机制。方法选择稳定期COPD合并PH患者45例、单纯性COPD患者40例,将45例COPD合并PH患者分为阿托伐他汀治疗组(23例)和对照组(22例)。比较治疗后两组血清中8-异前列腺素(8-iso-PG)、白介素-6(IL-6)水平及相关临床指标。结果单纯性COPD组、COPD合并PH组血清中IL-6水平分别为(43.58±13.38)ng/L和(72.80±21.60)ng/L,差异有统计学意义(P<0.01);两组血清中8-iso-PG水平分别为(27.79±11.09)ng/L与(41.87±9.75)ng/L,差异有统计学意义(P<0.01)。COPD合并PH患者血清IL-6和8-iso-PG水平与PASP呈正相关。阿托伐他汀治疗6个月后,治疗组血清8-iso-PG、IL-6、PASP较同组治疗前及对照组治疗后均有降低(P<0.01),PaO2、6MWD较同组治疗前及对照组治疗后均有升高(P<0.05)。结论阿托伐他汀能降低COPD合并PH患者肺动脉压力,改善血氧含量和运动耐力,其机制可能与其抑制炎症反应与氧化应激有关。

引用

页码：204 / 208

页数：5

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