白细胞介素-10对人牙龈成纤维细胞分泌白细胞介素-1β的抑制作用附视频

被引:3
作者
于新波
杨丕山
葛少华
机构
[1] 山东大学口腔医学院
关键词
白细胞介素类; 人牙龈成纤维细胞; 牙周炎;
D O I
暂无
中图分类号
R781.4 [牙周病];
学科分类号
摘要
目的 :探讨白细胞介素10 (IL10 )在牙周炎症反应中的抑制作用。方法 :用细胞培养法、酶联免疫吸附分析法(ELISA)检测细胞培养液上清中的IL1β浓度 ;用MTT法检测人牙龈成纤维细胞 (HGF)对细菌脂多糖 (LPS)、IL10的增殖反应。结果 :LPS以剂量依赖方式诱导HGF产生IL1β,6h达最大分泌量 ;IL1β的分泌可被IL10抑制 ,10ng/mlIL10作用 2 4h抑制效应达最大 ;LPS对HGF具有促增殖作用 ,而IL10对HGF的增殖无影响。结论 :IL10是一种抑制牙周炎症反应的细胞因子。
引用
收藏
页码:238 / 240
页数:3
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