抵抗素在非酒精性脂肪性肝病中的作用

被引：8

作者：

聂颖

聂菲

古赛

机构：

[1] 重庆医科大学附属第一医院

来源：

现代医药卫生 | 2013年 / 29卷 / 02期

关键词：

胰岛素抗药性; 脂肪肝; 脂类/代谢; 抵抗素; 非酒精性脂肪肝; 肝硬化; 综述;

D O I：

暂无

中图分类号：

R575.5 [肝代谢障碍];

学科分类号：

摘要：

<正>非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)是一种除酒精和其他明确损肝因素所致的、以弥散性肝细胞大泡性脂肪变性坏死为主要特征的临床病理综合征。21世纪是一个经济高速发展的时代,人们生活水平也相应得到进一步提高,随着饮食结构及人们生活方式的改变,相关代谢性疾病的发生率也有一定的升高[1]。相关统计得出,NAFLD与肥胖、2型糖尿病、高

引用

页码：233 / 234

页数：2

共 14 条

[1]

非酒精性脂肪性肝病诊疗指南[J]. 柳州医学. 2011 (02)

[2] 肿瘤坏死因子-α基因多态性与非酒精性脂肪性肝病的关系 [J].

周永健 ;

李瑜元 ;

聂玉强 ;

黄健 ;

石胜利 ;

李永强 ;

杜艳蕾 .

中华消化杂志, 2006, (05) :311-314

[3] 葡萄糖毒性、脂肪毒性与非酒精性脂肪性肝病 [J].

曾民德 .

中华肝脏病杂志, 2005, (02) :7-8

[4] Patients with nonalcoholic fatty liver disease display increased serum resistin levels and decreased adiponectin levels [J].

Jiang, Ling-Ling ;

Li, Lin ;

Hong, Xiao-Fei ;

Li, You-Ming ;

Zhang, Bing-Ling .

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 2009, 21 (06) :662-666

[5]

Effects of genetic variation in the visfatin gene ( PBEF1 ) on obesity, glucose metabolism, and blood pressure in children[J] . Metabolism . 2007 (6)

[6] Conditioned medium obtained from in vitro differentiated adipocytes and resistin induce insulin resistance in human hepatocytes [J].

Zhou, Lei ;

Sell, Henrike ;

Eckardt, Kristin ;

Yang, Zaiqing ;

Eckel, Yargen .

FEBS LETTERS, 2007, 581 (22) :4303-4308

[7] Influence of TNF gene polymorphisms in Japanese patients with NASH and simple steatosis [J].

Tokushige, Katsutoshi ;

Takakura, Mihoko ;

Tsuchlya-Matsushita, Noriko ;

Taniai, Makiko ;

Hashimoto, Etsuko ;

Shiratori, Keiko .

JOURNAL OF HEPATOLOGY, 2007, 46 (06) :1104-1110

[8]

Gene Expression of Leptin, Resistin, and Adiponectin in the White Adipose Tissue of Obese Patients with Non-Alcoholic Fatty Liver Disease and Insulin Resistance[J] . Ancha Baranova,Shobha J Gowder,Karen Schlauch,Hazem Elariny,Rochelle Collantes,Arian Afendy,Janus P Ong,Zachary Goodman,Vikas Chandhoke,Zobair M Younossi.Obesity Surgery . 2006 (9)

[9]

Resistin as an Intrahepatic Cytokine[J] . Cristiana Bertolani,Pau Sancho-Bru,Paola Failli,Ramon Bataller,Sara Aleffi,Raffaella DeFranco,Benedetta Mazzinghi,Paola Romagnani,Stefano Milani,Pere Ginés,Jordi Colmenero,Maurizio Parola,Stefania Gelmini,Roberto Tarquini,Giacomo Laffi,Massimo Pinzani,Fabio Marra.The American Journal of Pathology . 2006 (6)

[10] Increased serum resistin in nonalcoholic fatty liver disease is related to liver disease severity and not to insulin resistance [J].