依那普利对高血压病合并微白蛋白尿患者肾脏的保护作用

被引：4

作者：

郭冀珍

钱文琪

张慧丽

高平进

龚竺生

机构：

[1] 上海第二医科大学瑞金医院上海市高血压研究所

[2] 上海第二医科大学瑞金医院上海市高血压研究所上海

[3] 上海

来源：

中国临床药理学杂志 | 1992年 / 02期

关键词：

依那普利; 高血压病; 微量白蛋白尿; 尿白蛋白排泄率; 内生肌酐清除率; 肾脏保护作用;

D O I：

10.13699/j.cnki.1001-6821.1992.02.004

中图分类号：

学科分类号：

摘要：

本文比较了24例高血压病Ⅱ期患者服依那普利（enalapril）4—6周前后某些肾功能:尿微量白蛋白排泄率,内生肌酐清除率,尿IgG排泄率、血与尿β2微球蛋白。结果显示服药后血压,尿微量白蛋白排泄率及内生肌酐清除率均有明显改善。将24例分成正常（白蛋白排泄率<23mg/24h）及亚临床微量白蛋白尿组（23—100mg/24h）,发现前组服药前后尿微量白蛋白排泄率无明显改变而后组明显减少（从54.2±35.5到28.8±27.8mg/24h）。此外,按内生肌酐清除率90 l/24h,将24例分成内生肌酐清除率降低组及正常组,发现服药后前组明显升高（从71.6±12.6到101.1±22.1 l/24h）而后组不明显。因此,依那普利对高血压病Ⅱ期合并有微量白蛋白尿及/或肾小球滤过率降低患者比无合并者有更明显的肾保护作用。作者并对其病理生理机制做了初步探讨。

引用

页码：76 / 81

页数：6

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