髓源性抑制细胞与促炎因子在卵巢恶性肿瘤中的研究进展

被引：5

作者：

刘蓓

韩凌斐

机构：

[1] 同济大学附属第一妇婴保健院妇科

来源：

国际妇产科学杂志 | 2018年 / 45卷 / 01期

基金：

上海市自然科学基金;

关键词：

白细胞介素类; 前列腺素E类; 血管内皮生长因子类; 卵巢肿瘤; 免疫耐受; 免疫疗法; 髓源性抑制细胞;

D O I：

暂无

中图分类号：

R737.31 [卵巢肿瘤];

学科分类号：

100214 [肿瘤学];

摘要：

髓源性抑制细胞(myeloid derived suppressor cells,MDSCs)是一类具有显著免疫抑制活性的异质细胞群,包括处于不同分化阶段的未成熟的粒细胞、树突状细胞和巨噬细胞等。MDSCs可抑制CD4+、CD8+T细胞介导的适应性免疫应答,介导肿瘤免疫逃逸而促进肿瘤的生长和转移。促炎因子是一类主要由免疫细胞生成的具有许多强大生物学效应的内源性多肽,可介导多种免疫反应。MDSCs与促炎因子在卵巢癌中的分子信号传递及其机制仍不完全清楚,目前的研究提示部分促炎因子可诱导MDSCs扩增,进而促进肿瘤生长及发展。本文就MDSCs及相关促炎因子在卵巢恶性肿瘤中发生、发展和治疗的研究进行综述,以期更全面揭示MDSCs的作用机制,为探讨新的治疗方法提供理论基础。

引用

收藏

页码：55 / 59

页数：5

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