慢性应激抑郁模型大鼠强迫游泳后海马中c-fos的表达

被引：5

作者：

马慧

丁宝坤

谢守付

秦晓松

彭淼

金魁和

机构：

[1] 中国医科大学精神医学教研室

[2] 中国医科大学精神医学教研室沈阳

[3] 沈阳

来源：

中国神经精神疾病杂志 | 2003年 / 04期

关键词：

慢性应激; 抑郁障碍; 疾病模型; 强迫游泳; c-fos;

D O I：

暂无

中图分类号：

R749.4 [情感性精神病];

学科分类号：

100205 ;

摘要：

目的研究慢性应激对强迫游泳大鼠海马神经元c-fos表达的影响。方法采用特异性抗体的免疫组织化学方法,在大鼠慢性应激抑郁模型基础上,观察急性强迫游泳应激后海马神经元c-fos的表达情况。结果抑郁模型大鼠接受急性强迫游泳应激后,海马CA3区和齿状回(DG)内FOS蛋白的表达在各主要时点均比对照组降低,图像分析提示,上述两区域的FOS阳性神经元对应切面面积比明显降低(P<0.05),平均目标灰度值显著增加(P<0.05)。结论慢性应激使大鼠在急性强迫游泳应激后海马CA3区和DG内c-fos的表达降低。

引用

页码：296 / 299

页数：4

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