枳壳总黄酮提取物中柚皮苷和新橙皮苷在大鼠体内的组织分布

被引：9

作者：

陈海芳 ^{[1
,2
]}

张武岗 ^{[2
]}

袁金斌 ^{[1
,2
]}

魏莹 ^{[1
,2
]}

骆利平 ^{[1
,2
]}

杨武亮 ^{[1
,2
]}

机构：

[1] 江西中医学院现代中药制剂教育部重点实验室

[2] 江西中医学院

来源：

中国新药杂志 | 2014年 / 23卷 / 01期

关键词：

柚皮苷; 新橙皮苷; 组织分布;

D O I：

暂无

中图分类号：

R285 [中药药理学];

学科分类号：

100806 [中药药理学];

摘要：

目的:采用大鼠灌胃给药的方法考察枳壳中柚皮苷和新橙皮苷在大鼠体内的分布特征。方法:采用色谱柱Diamonsil C18(150 mm×4.6 mm,5μm),流动相为乙腈-0.1%甲酸水(20∶80),流速1.0 mL·min-1,柱温25℃,检测波长283 nm,进样量20μL,大鼠组织匀浆液经乙腈沉淀蛋白,氮吹处理甲醇定容后进行HPLC分析。结果:大鼠单次口服给药60 min后,柚皮苷和新橙皮苷浓度在各组织中均达到最大值,其中小肠和胃中的浓度非常高,其次是肺、脂肪、肌肉,肾、脾和脑,二者在肝和心的浓度较低;240 min后,柚皮苷和新橙皮苷在心、脾、肾、肌肉等组织浓度很低甚至没有。结论:柚皮苷和新橙皮苷在大鼠体内的分布相对广泛,胃和小肠是其主要分布器官,容易在胃和小肠中蓄积,其他组织中分布较少。

引用

页码：86 / 90

页数：5

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