ω-3多不饱和脂肪酸对免疫细胞功能的影响

被引：19

作者：

汪灏

黎介寿

机构：

[1] 南京军区南京总医院解放军普通外科研究所

来源：

肠外与肠内营养 | 2004年 / 05期

关键词：

多不饱和脂肪酸; 免疫细胞;

D O I：

10.16151/j.1007-810x.2004.05.017

中图分类号：

R459.3 [饮食疗法、临床营养学];

学科分类号：

摘要：

ω 3多不饱和脂肪酸 (PUFAs)是重要的营养组成成分。研究发现 ,ω 3多不饱和脂肪酸对风湿性关节炎、克隆病等自体免疫性疾病有较好的治疗作用。ω 3多不饱和脂肪酸对于机体免疫系统的影响越来越受到重视。近年来 ,已有大量文献报道。该作者重点总结了ω 3多不饱和脂肪酸对机体各种免疫细胞如T淋巴细胞 ,中性粒细胞 ,自然杀伤细胞及单核巨噬细胞的影响 ,并探讨了PUFAs对各种免疫细胞抑制的可能机制。这些机制包括PUFAs对细胞膜脂质成分的改变、对细胞内信号转导通路及基因表达的影响、对细胞凋亡的诱导以及对类花生酸类物质代谢的影响等 ,同时对其在炎症性疾病和器官移植中的应用进行了总结和展望。

引用

页码：304 / 308

页数：5

共 34 条

[1] n-3 fatty acid supplements in rheumatoid arthritis. Kremer, J.M. The American Journal of Clinical Nutrition . 2000
[2] Levelofpolyunsatu ratedfattyacidsandthen6ton3polyunsaturatedfattyacidra tiointheratdietalterserumlipidlevelsandlymphocytefunc tions. JefferyNM,NewsholmeEA,CalderPC. ProstaglandinsLeukotEssentFattyAcids . 1997
[3] Effectsofpurifieddietaryn3ethylestersonmurineTlymphocytefunction. FowlerKH,ChapkinRS,McMurrayDN. JImmunol . 1993
[4] Long-term supplementation with n-3 fatty acids, II: Effect on neutrophil and monocyte chemotaxis. Schmidt EB,Varming K,Pedersen J, et al. Scandinavian Journal of Clinical and Laboratory Investigation . 1992
[5] Di etaryfishoilinrenaltransplantrecipientstreatedwithcy closporin a:nobeneficialeffectsshown. KooijmansCoutinhoMF,RischenVosJ,HermansJetal. JAmSocNephrol . 1996
[6] The role of fish oils in the treatment of rheumatoid arthritis. Cleland LG,James MJ,Proudman SM. Drugs . 2003
[7] Oral administration of unsaturated fatty acids: effects on human peripheral blood T lymphocyte proliferation. Rossetti RG,Selier CM,DeLuca P et al. Journal of Leukocyte Biology . 1997
[8] Omega-3 fatty acids enhance tumor necrosis factor-alpha levels in heart transplant recipients. Holm T, Berge R K, Andreassen A K et al. Transplantation . 2001
[9] Dietary ome-ga-3 and omega-9 fatty acids uniquely enhance allograft survivalin cyclosporine-treated and donor-specific transfusion treated rats. Alexander JW,Valente J F,Greenberg NA,et al. Transplantation . 1998
[10] Dietary n-3 polyunsaturatedfatty acids modulate purified murine T-cell sub-set activation. Arrington JL,Chapkin RS,Switzer KC,et al. Clinical and Experimental Immunology . 2001

← 1 2 3 4 →