线粒体基因组与肿瘤耐药研究进展

被引:1
作者
黄伟
机构
[1] 华中科技大学同济医学院附属同济医院血液内科湖北武汉
关键词
线粒体基因; 凋亡; 耐药;
D O I
暂无
中图分类号
R73-36 [治疗实验];
学科分类号
100214 ;
摘要
线粒体基因主要编码细胞呼吸链成分及其特异性核糖体 ,线粒体DNA(mtDNA)影响细胞对凋亡诱导的耐受 ,从而影响肿瘤的耐药。mtDNA还影响P 糖蛋白 (P gp)蛋白水平及抗凋亡分子bcl 2及bcl xL表达。对mtDNA的研究可进一步揭示肿瘤耐药机制
引用
收藏
页码:348 / 350
页数:3
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