溃疡性结肠炎相关结直肠癌临床特点及癌变相关蛋白的表达

被引：20

作者：

李景南

郑威扬

钱家鸣

路新卿

杨红

机构：

[1] 中国医学科学院北京协和医学院北京协和医院消化科

来源：

中华消化杂志 | 2010年 / 11期

关键词：

结肠炎,溃疡性; 结肠腺瘤性息肉蛋白; β-连环蛋白;

D O I：

暂无

中图分类号：

R686 [筋腱、韧带、滑囊疾病及损伤];

学科分类号：

100220 [骨科学];

摘要：

目的探讨溃疡性结肠炎(UC)相关结直肠癌的临床特点及其癌变的可能机制。方法收集北京协和医院1984年至2008年6例UC相关性结直肠癌,分析其发病情况、临床表现、病理类型、治疗及预后特点,免疫组化检测组织标本中结肠腺瘤性息肉蛋白(APC蛋白)、β-连环蛋白、p53蛋白和Wnt1蛋白表达的情况。结果 UC的癌变率为1.1%(6/534),女性多见(5/6),平均病程14.3年。临床均呈现典型的UC表现,病变常累及全结肠(5/6),均无原发性硬化性胆管炎。其中直肠癌4例、降结肠癌2例,病理类型以腺癌为主,预后较差。APC蛋白、β-连环蛋白、p53蛋白和wnt1蛋白表达的阳性率分别为6/6、6/6、5/6和6/6。结论临床对病变累及全结肠、病程长的UC患者,应注意防止结直肠癌的发生,其癌变过程可能有多途径参与。

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