心肌细胞外基质的改变与心力衰竭

Cardiac extarellular matrix(ECM ) consists of several groups of extracellular macarelecules.In adultmyocardium, the major components of ECM includc collagen subtypes, fibronectin, laminin, metalloproteases(MMP), and tissue inhibitors of metalloproteases (TIMP). As a major component, cardiac collagen providesalignment to myocardial cells and serves as the skeleton of cardiac collagen network (CNW ), Which maintains theventricular chambers in normal structural architecture and function. Chronic congestive heart failure (CHF), anoutcome of a variety of cardiac diseases, is always associated with cardiac ECM remodeling including the changes ofcollagen synthesis, collagen deposition, acivation of MMP, and degradation of ECM. Those changes disrupt the cardiacCNW, which in turn causes the dilation of ventricular chambers, reduces the cardiac performance, and finallycontributes to the development of CHF.