皮质下脑卒中对运动想象有关脑区功能连接的影响

被引:14
作者
邵方方 [1 ]
尹大志 [1 ]
贾杰 [2 ]
赵智勇 [1 ]
王想敏 [1 ]
郑晓慧 [1 ]
宋凡 [2 ]
范明霞 [1 ]
孙莉敏 [2 ,3 ]
机构
[1] 华东师范大学上海市磁共振重点实验室
[2] 复旦大学附属华山医院康复科
[3] 上海市第三康复医院
关键词
脑卒中; 运动想象; 顶下小叶; 磁共振成像; 静息态功能连接;
D O I
暂无
中图分类号
R445.2 [核磁共振成像]; R743.3 [急性脑血管疾病(中风)];
学科分类号
100204 [神经病学]; 100231 [临床病理学];
摘要
目的:本研究拟运用静息态功能磁共振成像探讨皮质下脑卒中患者运动想象有关脑区功能连接状况。方法:对24例病灶位于左侧运动通路的皮质下脑卒中患者和年龄、性别相匹配的24例正常对照进行静息态脑功能磁共振成像扫描,以病变侧(左侧)顶下小叶为种子点,计算它与其他脑区的功能连接,利用双样本t检验对比分析两组受试者静息态功能连接差异。结果:与正常对照比较,脑卒中组的运动想象相关脑区之间功能连接发生显著变化。脑卒中组病变侧顶下小叶与病变对侧脑功能连接显著下降,涉及的脑区(顶下小叶、辅助运动皮质、运动前区、额下回岛盖部和枕中回)多于病变同侧(辅助运动皮质和运动前区);顶下小叶与病变同侧的额下回岛盖部和双侧小脑外侧部的功能连接显著增加。结论:静息态磁共振成像功能连接分析成功显示皮质下脑卒中导致运动想象相关脑区功能连接受损的客观存在。
引用
收藏
页码:133 / 139
页数:7
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