低氧细胞应激的HIF-1信号通路

被引：74

作者：

王苹苹

孔繁平

陈学群

杜继曾

机构：

[1] 浙江大学医学院基础医学系

来源：

浙江大学学报(医学版) | 2011年 / 05期

关键词：

低氧诱导因子1; 低氧; 反应元件; 转录因子;

D O I：

暂无

中图分类号：

R363 [病理生理学];

学科分类号：

100104 ;

摘要：

低氧诱导因子(hypoxia inducible factor,HIF)由HIF-1α和HIF-1β两个亚基组成,在低氧下其能激活多种靶基因的转录,在细胞、组织生长发育和生理应激,以及某些病理过程中具有重要的作用。近10年来,有关HIF-1在细胞低氧应激时的信号转导通路,特别是HIF-1α介导的基因转录调控的研究取得了巨大进展。

引用

页码：559 / 566

页数：8

共 8 条

[1] Hypoxia-Inducible Factors and the Response to Hypoxic Stress [J].

Majmundar, Amar J. ;

Wong, Waihay J. ;

Simon, M. Celeste .

MOLECULAR CELL, 2010, 40 (02) :294-309

[2] Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney [J].

Kume, Shinji ;

Uzu, Takashi ;

Horiike, Kihachiro ;

Chin-Kanasaki, Masami ;

Isshiki, Keiji ;

Araki, Shin-ichi ;

Sugimoto, Toshiro ;

Haneda, Masakazu ;

Kashiwagi, Atsunori ;

Koya, Daisuke .

JOURNAL OF CLINICAL INVESTIGATION, 2010, 120 (04) :1043-1055

[3]

Regulation of gene expression by hypoxia: Integration of the HIF-transduced hypoxic signal at the hypoxia-responsive element[J] . Stefan Kaluz,Milota Kaluzová,Eric J. Stanbridge.Clinica Chimica Acta . 2008 (1)

[4] HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity [J].

Zhang, Huafeng ;

Gao, Ping ;

Fukuda, Ryo ;

Kumar, Ganesh ;

Krishnamachary, Balaji ;

Zeller, Karen I. ;

Dang, Chi V. ;

Semenza, Gregg L. .

CANCER CELL, 2007, 11 (05) :407-420

[5] HIF-dependent hematopoietic factors regulate the development of the embryonic vasculature [J].

Ramirez-Bergeron, Diana L. ;

Runge, Anja ;

Adelman, David M. ;

Gohil, Mercy ;

Simon, M. Celeste .

DEVELOPMENTAL CELL, 2006, 11 (01) :81-92

[6]

The von Hippel–Lindau Tumor Suppressor Gene[J] . Keiichi Kondo,William G. Kaelin.Experimental Cell Research . 2001 (1)

[7]

HIF2alpha inhibition promotes p53 pathway activity,tumor cell death,and radiation res|xinses. Bertout J A,Majmundar AJ,Gordan JD.et al. Proceedings of the National Academy of Sciences of the United States of America . 2009

[8]

The aryl hydrocarbon receptor nuclear transporter is modulated by the SUMO-1 conjugation system. Tojo M,Matsuzaki K,Minami T, et al. Journal of Biological Chemistry . 2002

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