阿尔茨海默病患者中胰岛素与β样淀粉蛋白的关系

被引：2

作者：

周玢

洪震

黄茂盛

曾军

丁玎

金美华

吕传真

机构：

[1] 复旦大学华山医院神经病学研究所

来源：

中国神经精神疾病杂志 | 2003年 / 01期

关键词：

阿尔茨海默病; 胰岛素; β样淀粉蛋白;

D O I：

暂无

中图分类号：

R749.1 [脑器质性精神障碍];

学科分类号：

摘要：

目的研究阿尔茨海默病(AD)患者外周血胰岛素与β样淀粉蛋白水平的关系。方法患者为上海市1997-1998年的痴呆流行病学调查中的确诊病例,对照组为病例组的同社区居民,测定外周血的胰岛素与β样淀粉蛋白水平。结果 AD组的胰岛素水平(25.56±19.12μIU/mL)高于正常对照(15.88±11.05μIU/mL),两组相比有显著性差异(H=10.5,P<0.05),AD组β样淀粉蛋白水平(21.24±9.4 pg/mL)也高于对照(16.03±7.25 pg/mL)两组相比有显著性差异(H=13.1,P<0.05),随年龄的增长,90岁以前β样淀粉蛋白的量无明显变化,AD组与对照组的胰岛素量都呈下降趋势。β样淀粉蛋白与胰岛素(偏回归系数0.017,P>0.05)和年龄(偏回归系数0.082,P>0.05)差异没有显著性。结论 AD患者胰岛素水平与β样淀粉蛋白水平有关。

引用

页码：24 / 26

页数：3

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