可溶性尿激酶型纤溶酶原激活物受体在ICU感染患者病情严重程度及预后评价中的研究进展

被引:7
作者
杨静
董晨明
机构
[1] 兰州大学第二医院重症医学一科
关键词
可溶性尿激酶型纤溶酶原激活物受体; 重症监测治疗病房; 感染; 病情程度; 预后评估;
D O I
暂无
中图分类号
R459.7 [急症、急救处理];
学科分类号
100231 [临床病理学];
摘要
感染是引起重症监测治疗病房(ICU)患者死亡和不良预后的主要原因,对感染性疾病进行早期诊断、判断疾病严重程度、评估患者预后并指导有效地治疗可显著减少不良预后和病死率。可溶性尿激酶型纤溶酶原激活物受体(suPAR)是一种新型的炎性反应标志物,在各种感染性疾病中其表达水平会升高,具有较高的诊断价值;可作为一种独立风险因子,预测ICU重症患者的不良预后;同时也是ICU患者疾病严重程度的标志。
引用
收藏
页码:1769 / 1772
页数:4
相关论文
共 9 条
[1]
Diagnostic accuracy of soluble urokinase plasminogen activator receptor (suPAR) for prediction of bacteremia in patients with systemic inflammatory response syndrome [J].
Hoenigl, Martin ;
Raggam, Reinhard B. ;
Wagner, Jasmin ;
Valentin, Thomas ;
Leitner, Eva ;
Seeber, Katharina ;
Zollner-Schwetz, Ines ;
Krammer, Werner ;
Prueller, Florian ;
Grisold, Andrea J. ;
Krause, Robert .
CLINICAL BIOCHEMISTRY, 2013, 46 (03) :225-229
[2]
The diagnostic and prognostic significance of soluble urokinase plasminogen activator receptor in systemic inflammatory response syndrome.[J]..Clinical Biochemistry.2011, 14
[3]
Soluble urokinase plasminogen activator receptor (suPAR) for assessment of disease severity in ventilator-associated pneumonia and sepsis [J].
Savva, Athina ;
Raftogiannis, Maria ;
Baziaka, Fotini ;
Routsi, Christina ;
Antonopoulou, Anastasia ;
Koutoukas, Pantelis ;
Tsaganos, Thomas ;
Kotanidou, Anastasia ;
Apostolidou, Efterpi ;
Giamarellos-Bourboulis, Evangelos J. ;
Dimopoulos, George .
JOURNAL OF INFECTION, 2011, 63 (05) :344-350
[4]
suPAR: The molecular crystal ball.[J].Joel Fleury Djoba Siawaya.Disease Markers.2009; 3,4
[5]
uPA impairs cerebrovasodilation after hypoxia/ischemia through LRP and ERK MAPK.[J].William M. Armstead;Douglas B. Cines;Khalil Bdeir;Irina Kulikovskaya;Sherman C. Stein;Abd Al-Roof Higazi.Brain Research.2008,
[6]
Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock [J].
Dellinger, RP ;
Carlet, JM ;
Masur, H ;
Gerlach, H ;
Calandra, T ;
Cohen, J ;
Gea-Banacloche, J ;
Keh, D ;
Marshall, JC ;
Parker, MM ;
Ramsay, G ;
Zimmerman, JL ;
Vincent, JL ;
Levy, MM .
CRITICAL CARE MEDICINE, 2004, 32 (03) :858-873
[7]
Soluble urokinase receptor is elevated in cerebrospinal fluid from patients with purulent meningitis and is associated with fatal outcome [J].
Ostergaard, C ;
Benfield, T ;
Lundgren, JD ;
Eugen-Olsen, J .
SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, 2004, 36 (01) :14-19
[8]
Soluble urokinase receptor (uPAR; CD 87) is present in serum and cerebrospinal fluid in patients with neurologic diseases.[J].Juan Carlos Garcia-Monco;James L Coleman;Jorge L Benach.Journal of Neuroimmunology.2002, 1
[9]
中枢神经系统感染患者脑脊液中suPAR、sICAM-1的变化及意义 [J].
孙颖 ;
王翠兰 ;
刘持善 ;
孙东 ;
陶秀兰 ;
邓小梅 .
中国临床神经科学, 2007, (04) :387-391