槲皮素降低大鼠心率和心肌钙振荡频率和抑制小鼠心肌肥厚(英文)

被引：4

作者：

王瑜

汪红仪

袁肇侃

赵晓宁

王金晞

张祖暄

机构：

[1] 南京大学医学院

[2] 南京大学配位化学国家重点实验室

[3] 南京大学医学院南京中国

来源：

ActaPharmacologicaSinica | 1999年 / 05期

关键词：

槲皮素; 心动过缓; 心肌; 培养的细胞; 钙; 左心室肥大; 异丙肾上腺素; 哇巴因; 主动脉缩窄; 血管紧张素Ⅱ;

D O I：

暂无

中图分类号：

R96 [药理学];

学科分类号：

100602 ; 100706 ;

摘要：

目的:研究槲皮素对心肌兴奋收缩耦联及构型重建的影响。方法:经动脉插管记录大鼠血流动力学;缩窄小鼠腹主动脉致心肌肥厚;检测Fura 2-AM负载的培养大鼠心肌细胞内游离钙([Ca2+]i)及钙振荡,结果:槲皮素剂量相关地降低大鼠窦性心率,而动脉血压、左室压及其微分改变轻微;10-250 μmol·L-1时浓度依赖性降低培养心肌自发钙振荡频率,100μmol·L-1时预防异丙肾上腺素及哇巴因加速钙振荡频率,但不抑制静息[Ca2+]i.和自发钙振荡及二药增高的振荡幅度,槲皮素还抑制血管紧张素Ⅱ而非高钾的升[Ca2+]i作用,槲皮素120 mg·kg-1·d-15 d灌胃不改变假手术鼠的心室与体重之比,但显著抑制腹主动脉结扎小鼠的心室肥大,结论:槲皮素降低心肌钙振荡频率和心肌肥厚但不直接影响心脏兴奋收缩耦联。

引用

页码：44 / 48

页数：5

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