PGC-1α在心血管疾病中的重要作用及机制

被引：10

作者：

唐楠

刘方圆

杨振

樊迪

邓伟

唐其柱

机构：

[1] 武汉大学人民医院心内科、武汉大学心血管病研究所、心血管病湖北省重点实验室

来源：

医学研究杂志 | 2019年 / 48卷 / 01期

关键词：

过氧化物酶体增殖物激活受体γ辅激活子1ɑ; 心肌肥厚; 动脉粥样硬化; 心肌缺血;

D O I：

暂无

中图分类号：

R54 [心脏、血管（循环系）疾病];

学科分类号：

100201 [内科学];

摘要：

PGC-1α是近年来备受关注的核受体辅助激活因子,通过与PPARs、NRFs和ERRs等核受体相互作用,调节线粒体的生物合成,物质和能量代谢以及抗氧化应激,因而奠定其在心脏中的重要作用。本文就PGC-1α在心肌肥厚、心力衰竭、心肌病、动脉粥样硬化以及心肌缺血等心血管疾病中的做用及机制做简要阐述。

引用

页码：18 / 22

页数：5

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