肝癌中COX-2蛋白与MMP-2蛋白的表达及其相关性研究

被引：2

作者：

刘玮

冯浩

刘瑞文

马春海

机构：

[1] 江苏大学附属昆山市第一人民医院普外科

来源：

交通医学 | 2008年 / 22卷 / 06期

关键词：

环氧化酶-2; 基质金属蛋白酶-2; 肝细胞癌; 免疫组织化学;

D O I：

暂无

中图分类号：

R735.7 [肝肿瘤];

学科分类号：

摘要：

目的:探讨环氧化酶-2(COX-2)与基质金属蛋白酶-2(MMP-2)在肝细胞癌(HCC)中表达的相关性和临床意义。方法:应用免疫组化SP法检测47例HCC组织、33例癌旁组织COX-2蛋白和MMP-2蛋白的表达。结果:COX-2蛋白在HCC组织、癌旁组织中的阳性表达率分别为78.7%,30.3%(P<0.05),COX-2蛋白的表达与肿瘤分化程度、肝硬化、静脉浸润以及TNM分期相关(P<0.05);MMP-2蛋白在HCC组织、癌旁组织中的阳性表达率分别为68.1%,39.4%(P<0.05),MMP-2蛋白的表达与肿瘤大小、分化程度、静脉浸润、TNM分期相关(P<0.05)。COX-2与MMP-2同时阳性表达者为25例。结论:COX-2蛋白和MMP-2蛋白在HCC组织中表达上调,并呈正相关(P<0.01),证实COX-2和MMP-2在HCC发生发展过程中起重要作用。

引用

页码：639 / 641+646 +646

页数：4

共 13 条

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