抗MRSA抗生素研究新进展

被引：4

作者：

顾觉奋

施媚

机构：

[1] 中国药科大学

[2] 中国药科大学南京

[3] 南京

来源：

国外医药(抗生素分册) | 2004年 / 05期

关键词：

MRSA; 抗生素; PBP2a;

D O I：

10.13461/j.cnki.wna.003971

中图分类号：

R978.1 [抗生素];

学科分类号：

100705 ;

摘要：

近年来一些新的抗MRSA抗生素研究陆续有报道 ,包括 β -内酰胺类 ,其中有头孢菌素类 (BMS -2 472 43、BAL914 1、RWJ -5 44 2 8、S -3 5 78、NB2 0 0 1)、新碳青霉烯类 (Cs -0 2 3、J -111,2 2 5、J -114 ,870和J -114 ,871)、甘氨四环素类 (GAR -93 6)、十七糖酐 (saccharomicinsA和B)、糖肽类 (oritavancin、dalbavancin)、肽聚糖合成的抑制剂 (katanosinB和 plusbacinA3 )、脂肽类 (达托霉素、雷莫拉宁 ) ,这些药物在以下方面有所进展 :( 1)提高抗菌活性 ;( 2 )克服产 β -内酰胺酶的耐药机制 ;( 3 )阻碍了细胞壁的形成。从而为治疗MRSA感染带来了希望

引用

页码：216 / 220

页数：5

共 11 条

[1]

In vitro and in vivo activities of tigecycline (GAR- 936), daptomycin, and comparative antimicrobial agents against glycopeptide- intermediate Staphylococcus aureus and other resistant gram-positive pathogens. Petersen PJ,Bradford PA,Weiss WJ,et al. Antimicrobial Agents and Chemotherapy . 2002

[2]

BAL9141, a novel extended-spectrum cephalosporin active against methicillin-resistant Staphylococcus aureus in treatment of experimental endocarditis. Entenza JM,Hohl P,Heinze- Krauss I,et al. Antimicrobial Agents and Chemotherapy . 2002

[3]

In vitro activity of cephalosporin RWJ-54428 (MC-02479) against multidrug- resistant gram - positive cocci. Johnson AP,Warner M,Carter M,et al. Antimicrobial Agents and Chemotherapy . 2002

[4]

Resistance studies with daptomycin. Jared A,Oliver N,Andrew T,et al. Antimicrobial Agents and Chemotherapy . 2001

[5]

Saccharomicins,novel heptadecaglycoside antibiotics produced by saccharothrix espanaensis: antibacterial and mechanistic activities. Singh MP,Petersen PJ,Weiss WJ,et al. Antimicrobial Agents and Chemotherapy . 2000

[6]

Katanosin B and Plusbacin A3,inhibitors of peptidoglycan synthesis in methicillin - resistant Staphylococcus aureus. Maki H,Miura K,Yamano Y. Antimicrobial Agents and Chemotherapy . 2001

[7]

In vivo pharmacodynamic activities of two glycylcyclines (GAR-936 and WAY 152, 288) against various gram-positive and gram-negative bacteria. Ogtrop ML,Andes D,Stamstad TJ,et al. Antimicrobial Agents and Chemotherapy . 2000

[8]

Total synthesis of the ramoplanin A2 and ramoplanose aglycon. Jiang WL,Jutta W,Richard JL,et al. Journal of the American Chemical Society . 2002

[9]

In vitro and in vivo activities of a novel cephalosporin, BMS - 247243, against methicillin-resistant and susceptible staphylococci. Fung-Tomc JC,Clark J,Minassian B,et al. Antimicrobial Agents and Chemotherapy . 2002

[10]

In vitro activity of LY333328 (oritavancin) against gram- positive aerobic cocci and synergy with ciprofloxacin against enterococci. Noviello S,Ianniello F,Esposito S. Journal of Antimicrobial Chemotherapy . 2001

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