肿瘤精准细胞免疫治疗:梦想照进现实

被引：27

作者：

钱其军

吴孟超

机构：

[1] 第二军医大学东方肝胆外科医院

来源：

中国肿瘤生物治疗杂志 | 2015年 / 22卷 / 02期

关键词：

精准医疗; 肿瘤; 精准细胞免疫治疗; 精准T细胞; 嵌合抗原受体T细胞;

D O I：

暂无

中图分类号：

R730.51 [免疫疗法];

学科分类号：

摘要：

精准医疗(precision medicine)作为一种全新的医学概念与医疗模式,已日益在恶性肿瘤临床治疗中显示其价值。精准细胞免疫治疗(precision cell immunotherapy,PCIT)是基于肿瘤患者基因检测,筛选可引起强烈免疫反应的新抗原(neoantigen),进而寻找并富集针对新抗原的精准T细胞(precision T cell for neo-antigen,PNA-T),扩增后回输患者的治疗新策略。相对于其他精准医学治疗方式,精准细胞免疫治疗具有比较独特的优势,有望成为中国肿瘤精准医学治疗的重要突破口。本文围绕肿瘤精准细胞免疫治疗面临的机遇与挑战,从概念、特点、流程、技术难点等方面进行了详细阐述,并对比了其与转基因嵌合抗原受体T细胞(chimeric antigen recepor T cell,CAR-T)的异同,勾勒出肿瘤精准细胞免疫治疗的美好前景。

引用

页码：151 / 158

页数：8

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