miRNA在肝癌中的价值

被引:5
作者
王丹 [1 ]
张涛 [2 ]
机构
[1] 西南医科大学
[2] 中国人民解放军成都军区总医院肿瘤科
关键词
miRNA; 血清miRNA; 肝癌; 诊断; 预后;
D O I
暂无
中图分类号
R735.7 [肝肿瘤];
学科分类号
摘要
肝癌是我国常见恶性肿瘤之一,具有高度侵袭性和复发率,大部分肝癌患者就诊时已经进入中晚期,错失了最佳治疗时机,且预后较差,因此寻找早期肝癌诊断和预后判断的生物分子标志物是十分必要的。MicroRNA(miRNA)是一类内源性、长度为20~25个核苷酸的非编码小RNA,在血清或血浆中表现出高度的稳定性。大量研究表明miRNA在肿瘤中起着促癌基因或抑癌基因的作用,并能同时调节多个靶基因,参与肿瘤的发生发展。因此,肝癌患者和正常人血清样本中表现出显著差异的miRNA可能对肝癌患者的诊断和预后有着潜在的指示作用。
引用
收藏
页码:158 / 160
页数:3
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