儿童幽门螺杆菌对克拉霉素的耐药状况及耐药机制

被引:4
作者
余金丹
机构
[1] 浙江大学医学院附属儿童医院消化科浙江 杭州 
关键词
螺杆菌; 幽门; 6-O-甲基红霉素; 药物耐受性;
D O I
暂无
中图分类号
R725.7 [小儿消化系及腹部疾病];
学科分类号
摘要
克拉霉素(clarithromycin,CLM)是根治幽门螺杆菌(helicobater pylori,HP)感染疗效最强的抗生素之一,研究表明,HP对CLM的耐药性是造成含CLM联合方案根治失败的主要原因,其耐药机制主要为HP23S rRNA基因V区点突变,使核糖体结合部位构象发生改变,从而药物与HP核糖体的亲和力明显下降。研究其耐药状况及耐药机制,对临床治疗有指导作用。现将国内外关于儿童HP对CLM耐药问题的研究进展作一综述。
引用
收藏
页码:228 / 230
页数:3
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