斑马鱼模型在药物毒性与安全性评价中的应用

被引：24

作者：

陈汝家 ^{[1
]}

朱俊靖 ^{[1
]}

周盛梅 ^{[1
]}

辛艳飞 ^{[2
]}

宣尧仙 ^{[2
]}

李春启 ^{[1
]}

机构：

[1] 杭州环特生物科技有限公司

[2] 浙江省医学科学院安全性评价研究中心

来源：

毒理学杂志 | 2012年 / 26卷 / 03期

关键词：

斑马鱼; 药物毒性与安全性评价; 体内分析;

D O I：

10.16421/j.cnki.1002-3127.2012.03.022

中图分类号：

R965 [实验药理学];

学科分类号：

100602 ; 100706 ;

摘要：

<正>目前国际上公认的药物毒性与安全性评估实验方法分为体外与体内实验2种。体外实验具有快速、高效和经济等优点,但体外实验通常不涉及药物在体内的吸收、分布、代谢与排泄,因此筛选结果与整体动物试验结果可比性差。体内实验能提供可比性较高的筛

引用

页码：224 / 228

页数：5

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