黄芪甲苷在心血管疾病中的作用

被引：27

作者：

李香华

王洪新

机构：

[1] 辽宁医学院细胞生物学与新药开发重点实验室

来源：

心血管病学进展 | 2011年 / 32卷 / 01期

关键词：

黄芪甲苷; 心肌细胞结构; 心血管疾病;

D O I：

暂无

中图分类号：

R285.5 [中药实验药理];

学科分类号：

1008 ;

摘要：

黄芪甲苷具有广泛的药理作用,其中包括抗糖尿病、抗高血压、抗炎症以及保护心肌抗心力衰竭作用。目前研究表明黄芪甲苷可减少心肌细胞损伤和阻止内皮细胞功能障碍。黄芪甲苷对能量代谢综合征发病机制有不同的药理作用。黄芪甲苷有望成为一种新药用于治疗心血管疾病。

引用

页码：132 / 136

页数：5

共 38 条

[1] Astragaloside IV dilates aortic vessels from normal and spontaneously hypertensive rats through endothelium-dependent and endothelium-independent ways [J].

Zhang, Wei-Dong ;

Zhang, Chuan ;

Wang, Xu-Hui ;

Gao, Ping-Jin ;

Zhu, Ding-Liang ;

Chen, Hong ;

Liu, Run-Hui ;

Li, Hui-Liang .

PLANTA MEDICA, 2006, 72 (07) :621-626

[2] Astragaloside IV improved barrier dysfunction induced by acute high glucose in human umbilical vein endothelial cells [J].

Li, Han-Bing ;

Ge, Ya-Kun ;

Zhang, Le ;

Zheng, Xiao-Xiang .

LIFE SCIENCES, 2006, 79 (12) :1186-1193

[3]

Modification of alterations in cardiac function and sarcoplasmic reticulum by astragaloside IV in myocardial injury in vivo[J] . Xiao-Le Xu,Hui Ji,Shu-Yi Gu,Qin Shao,Qiu-Ju Huang,Yan-Ping Cheng. &nbspEuropean Journal of Pharmacology . 2007 (1)

[4] Patterns of structural and functional remodeling of the left ventricle in chronic heart failure [J].

Gaasch, William H. ;

Delorey, Dennis E. ;

Sutton, Martin G. St. John ;

Zile, Michael R. .

AMERICAN JOURNAL OF CARDIOLOGY, 2008, 102 (04) :459-462

[5]

Mitochondrial function in cardiomyocytes: target for cardioprotection. Das DK,Maulik N. Curr Opin Anaesthesiol . 2005

[6]

Effects of astragaloside IV on heart failure in rats. Zhao Z,Wang W,Wang F, et al. Chinese Medical Journal . 2009

[7]

Astragaloside IV improved barrier dysfunction induced by acute high glucose in human umbilical vein endothelial cells. Li HB,Ge YK,Zhang L, et al. Life Sciences . 2006

[8]

Antiinflammatory activity of astragaloside IV is mediated by inhibition of NF-kappaB activation and adhesion molecule expression. Zhang WJ,Hufnagl P,Binder BR,et al. Thrombosis and Haemostasis . 2003

[9]

Patterns ofstructural and functional remodeling of the left ventricle in chronicheart failure. Gaasch WH,Delorey DE,St John Sutton MG,et al. The American Journal of Cardiology . 2008

[10]

Astragaloside IVdilatesaortic vessels from normal and spontaneously hypertensive ratsthrough endothelium-dependent and endothelium-independent ways. Zhang W D,Zhang C,Wang X H,et al. Planta Medica . 2006

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