首发精神分裂症患者威斯康星卡片分类测验中的脑功能障碍研究

被引：14

作者：

舒畅

肖玲

王熇生

王惠玲

王高华

机构：

[1] 武汉大学人民医院精神卫生中心

来源：

神经损伤与功能重建 | 2014年 / 9卷 / 03期

关键词：

精神分裂症; 功能性磁共振; 威斯康星卡片分类测验; 前额叶皮质;

D O I：

暂无

中图分类号：

R741 [神经病学]; R749.3 [精神分裂症];

学科分类号：

100204 [神经病学];

摘要：

目的:探讨首发未服药精神分裂症患者进行威斯康星卡片分类测验(WCST)操作时的脑功能状态特点。方法:20名健康受试者(对照组)和20名首发未服药精神分裂症患者(患者组)操作WCST和颜色卡片分类测验(CCST)时进行脑功能磁共振成像(fMRI),比较2组激活脑区的激活体积。结果:对照组WCST和CCST功能图像相减获得的脑活动功能图像显示,激活主要分布在双侧前额叶,尤其是背外侧部以及顶叶后下部皮质和前扣带回。患者组WCST操作成绩较对照组差,有显著性差异(P<0.01)。与对照组相比,患者组的左侧前额叶背外侧部、左前扣带回皮质激活低下,左顶叶后下部皮质激活增加(P<0.01或0.05)。结论:双侧前额叶,尤其是背外侧部,以及顶叶后下部皮质和前扣带回皮质参与WCST操作的高级认知过程。精神分裂症患者在未治疗前就存在执行功能缺陷,其前额叶和扣带回功能低下,可能与患者执行功能障碍相关;后顶叶皮质功能亢进,可能对前额叶功能低下有补偿作用。

引用

页码：233 / 235

页数：3

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