The Time-Effect Relationship of Central Action in Acupuncture Treatment for Weight Reduction

Purpose:To study the time-effect relationship of action of acupuncture on the satiety center of ventromedialnucleus of hypothalamus(VMH)in rats with experimental obesity.Methods:Microelectrode recordingmethod of nerve cells and stereotaxic technique for brain were adopted with discharge frequency(Hz/s)ofnerve impulse in VMH as the index,and the time-effect of acupuncture action in different periods betweengroups were observed.Results:Electric activity in acupuncture group was higher than that in the obesitymodel group(P<0.001)and the normal group(P<0.01)respectively,and the curve of acupuncture actionwithin 2 hours showed irregular fluctuation.Conclusion:Acupuncture can increase excitability of the satietycenter,with a better long-term effect.