噻托溴铵治疗慢性阻塞性肺疾病独特的作用

被引：5

作者：

卞如濂

机构：

[1] 浙江大学医学院国家呼吸药物研究实验室

来源：

国际呼吸杂志 | 2010年 / 01期

关键词：

D O I：

暂无

中图分类号：

R563 [肺疾病];

学科分类号：

100201 [内科学];

摘要：

<正>噻托溴铵对慢性阻塞性肺疾病（chronicobstructive pulmonary disease,COPD）维持治疗有重要作用,不少临床报道都肯定这点。该药被认同为治疗COPD的一线药物。新近Donald等报道,噻托溴铵对5 593例中、重度COPD患者为期4年治疗肺功能潜在长期疗效研究（即UPLIFT研究）,结果证实以下几点:①能增加第1秒用力呼气容积（FEV1）与用力肺活量（FVC）值,改善肺功能;②能明显推迟首次急性加重的发生时间;③减少每年急性加重次数（约减少14%）;④降低由急性加重导致的患者住院率;⑤降低治疗期间死亡率:⑥明显并持续提高患者的健康相关生活质量,圣.乔治呼吸

引用

共 8 条

[1]

Effect of Tiotropium on Cough Reflex Sensitivity in Acute Viral Cough [J].

Dicpinigaitis, Peter V. ;

Spinner, Leah ;

Santhyadka, Ganesha ;

Negassa, Abdissa .

LUNG, 2008, 186 (06) :369-374

[2]

Suppressive activity of tiotropium bromide on matrix metalloproteinase production from lung fibroblasts in vitro.[J].Kazuhito Asano.International Journal of Chronic Obstructive Pulmonary Disease.2008, Issu

[3]

Tiotropium suppresses acetylcholine-induced release of chemotactic mediators in vitro [J].

Buehling, Frank ;

Lieder, Nadine ;

Kuehlmann, Ulrike C. ;

Waldburg, Nadine ;

Welte, Tobias .

RESPIRATORY MEDICINE, 2007, 101 (11) :2386-2394

[4]

Acetylcholine-induced proliferation of fibroblasts and myofibroblasts in vitro is inhibited by tiotropium bromide.[J].M.P. Pieper;N.I. Chaudhary;J.E. Park.Life Sciences.2007, 24-2

[5]

The non-neuronal cholinergic system in the airways: An unappreciated regulatory role in pulmonary inflammation? [J].

Gwilt, Catherine R. ;

Donnelly, Louise E. ;

Rogers, Duncan F. .

PHARMACOLOGY & THERAPEUTICS, 2007, 115 (02) :208-222

[6]

The connection between chronic obstructive pulmonary disease symptoms and hyperinflation and its impact on exercise and function [J].

Cooper, Christopher B. .

AMERICAN JOURNAL OF MEDICINE, 2006, 119 (10) :S21-S31

[7]

The pharmacodynamic effects of single inhaled doses of formoterol, tiotropium and their combination in patients with COPD [J].

Cazzola, M ;

Di Marco, F ;

Santus, P ;

Boveri, B ;

Verga, M ;

Matera, MG ;

Centanni, S .

PULMONARY PHARMACOLOGY & THERAPEUTICS, 2004, 17 (01) :35-39

[8]

The efficacy and safety of tiotropium in Chinese patients with stable chronic obstructive pulmonary disease:a meta-analysis..Wu Q;Li G;Lei WI;et al;.Respirology.2009, 14

← 1 →